Serum IgG, and IgM Levels in Children with Febrile Convulsions

  • Gulhis Deda Department of Pediatric Neurology, Dr. Sami Ulus Children's Hospital, Ankara, Turkiye
  • Ugur Karagol Department of Pediatric Neurology, Dr. Sami Ulus Children's Hospital, Ankara, Turkiye
  • Ya Vuz Gurer Department of Pediatric Neurology, Dr. Sami Ulus Children's Hospital, Ankara, Turkiye
DOI: https://doi.org/10.14238/pi33.1-2.1993.15-9
Keywords: serum IgG; IgM; febrile convulsion; IgA

Abstract

At the Dr. Sami Ulus Children's Hospital Ankara, Turkiye, 20 patients, twelve being between 6 months-2 year old and eight being between 2-4 years, with their first febrile convulsions (FC) were examined for serum IgG, IgA, IgM levels during the period of March 1989-]uly 1989. Twenty healthy children were used as controls, seven being between 6 months-2 years old and thirteen being between 2-6 years. The serum IgG, IgA and IgM levels of the patients between 6 months-2 years were 805.000 + 307.8984 mg/ dl, 49.7167 + 27.9807 mg/dl and i55.1833 + 62.9696 mg/dl respecttvelly.

The serum IgG, IgA and IgM levels of the patients between 2-4 years were : 989.1250 ± 314.5359 mg/dl, 92.6125 ± 34.5663 mg/dl and 159.8750 ± 45.6647 mg.ldl respectivelly. The mean IgA levels of the 12 FC patients between 6 months-2years were 49.7167 ± 27.9807 mg/dl and the mean level of IgA in the age matched control group was 81.0427± 31.3551 mg/dl and the difference between them was statistically significant (p <0. 005).

We conclude that FC under 2 years of age is associated with low serum IgA levels.

References

1. Addy DP. Febrile convulsion. In: Paediatric perpectives on Epilepsi. john Wiley and Sons ltd, 1985; 73-7.
2. Niall V O'Donohoe. Febrile Convulsions. In: Epileptic syndromes in infancy, childhood and adolescence. john Libbey Eurotex, 1985; 34-7 .
3. Bell and Me Cormik. Febrile Seizures. In: Neurologic Infections in Children. WB Saunders 1975, 444-7.
4. Erenberg G. Febrile Convulsions; A new look at an old Problem. Cleveland Clinic Quarterly Vol 51, no 2.
S. Joffe A, Mc Cormik M, De Angelis C . Which children with febrile seizures need lumber puncture? Am J Dis Child 1983; 137: 1153-6.
6. Lewis HM, Parry JV, Parry RP et al. Role of viruses in febrile convulsions. Arch Dis Child 1979; 54 ; 869-76.
7. Nelson K. Febrile Seizures In: The practice of pediatric Neurology. 2nd ed. Mosby 1982; 1070-4 .
8. Schmidt D, lsai D. janz D . Febrile seizures in patients with complex partial seizures. Acta Neurol Scand 1985; 72: 68-71.
9. Seager J, jamison DL, Wilson ], Hayward AR, Soothill JF . IgA deficiency, epilepsy and phenytoin treatment. Lancet 1975; ii: 632-5.
10. Ariizumi M, Kuromori S, Shiihara H, Eguchi H, Baba K . Febrile convulsion and Immunoglobulin Abnormalities. Nihon Univ J Med 1980; 22 : 195- 201.
11. Fahey jL, Me Kelvey EM . Quantitative determination of serum immunoglobulins in antibody agar plates. J lmmunol196S; 94-84 .
12. Amos JR, Brown FL, Mink OG. Chi-Square Test. In: Statistical Concepts. A Basic program. New York: Harper and Row, 1965; 90-2.
13. Takayuki T, Shigeko O. Exogenous causes of Neu.rol Scand 19SS;. 71 : 107-13 .
14. Verity CM, Butter NR, Colding J . Febrile convulsion in a national cohort follow up from birth. 1-previllance and recurrence in the first five years of life. Br Med.
15. Viani F, Begni E, Romeo A, Van Lierde A. Infantile febrile status epilepticus: Risk factors and outcome. Develop Med Child Neurol 1987; 29: 495-501.
16. Hauser WA, Annegers JF, Anderson VF, Kurland LT. The risk of seizure disorders among relative of children with febrile convulsions. Neurology 1985; 35: 1268-73.
17. Olofsson OE, Wigertz A, H Link. Immunoglobulin abnormalities in seizure. Neuropediatrics 1982; 13 : 39-41.
18. Gibus NE, AarlijA . lmmunoglobulin concentration in patients with a history of febrile convulsions prior to the development of epilepsy. Neuropediatrics 1981 ; 12:·314-8.
19. 1saacs D, Webster ADB, Valman HB. Serum immunoglobulin concentrations in febrile convulsions. Arch Dis Child 1984; 59: 367-9.
20. Tartara A, Verri AP, Nespoli L, Moglia A, Borui MG . Immunoglogical findings in epileptic and febrile convulsion patients before and under treatment. Eur Neurol 1981; 20: 306-11.
Published
2018-12-11
How to Cite
1.
Deda G, Karagol U, Gurer Y. Serum IgG, and IgM Levels in Children with Febrile Convulsions. PI [Internet]. 11Dec.2018 [cited 26Apr.2024];33(1-2):15-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2050
Issue
Vol 33 No 1-2 (1993): January - February 1993
Section
Pediatric Neurology

Copyright (c) 2018 Gulhis Deda, Ugur Karagol, Ya Vuz Gurer

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Received 2018-12-11
Published 2018-12-11