Artesunate-amodiaquine versus artesunatesulfadoxine- pyrimethamine for uncomplicated falciparum malaria in children

Novie H. Rampengan; Jane Metusala; Ronald Chandra; Praevilia Salendu

doi:10.14238/pi54.1.2014.46-51

Novie H. Rampengan Departement of Child Health, Sam Ratulangi University Medical School/ProÂ£ Dr. R.D. Kandou Hospital
Jane Metusala Departement of Child Health, Sam Ratulangi University Medical School/ProÂ£ Dr. R.D. Kandou Hospital
Ronald Chandra Departement of Child Health, Sam Ratulangi University Medical School/ProÂ£ Dr. R.D. Kandou Hospital
Praevilia Salendu Departement of Child Health, Sam Ratulangi University Medical School/ProÂ£ Dr. R.D. Kandou Hospital

DOI: https://doi.org/10.14238/pi54.1.2014.46-51

Keywords: uncomplicated malaria falciparum, artesunate, amodiaquine, sulfadoxinepyrimethamine.

Abstract

Background Malaria is a major cause of morbidity and mortality
in children, especially in developing countries. Art emisinin
combination therapy (ACT) has higher rates of parasite clearance
and inhibition of anti-malarial drugs resistance than non-ACT.
Hence, we compared the efficacies of artesunate-amodiaquine
(AS-AQ) versus artesunate-sulfadoxine pyrimethamine (AS-SP)
combination therapies in children with uncomplicated falciparum
malaria.
Objective To compare the fever clearance time, parasite clearance
time, and length of hospital stay in uncomplicated falciparum
malaria patients treated with AS-AQ and AS-SP.
Methods We reviewed the medical records of children aged 1- 14
years with uncomplicated falciparum malaria admitted to Prof.
Dr. R. D. Kandou Hospital between January 2002 - June 2010.
Treatment efficacy was evaluated by fever clearance time, parasite
clearan ce time, and length of hospital stay. The differences
of treatment efficacy between the two groups of therapy were
an alyzed by independent T test.
Results We identified 185 children with uncomplicated
falciparum malaria, 104 cases were treated with AS-AQ while
the other 81 received AS-SP. Parasite clearance time was shorter
in AS-AQ group than in AS-SP group at 1.38 (SD 0.69) versus
1.91 (SD 0.93) days, respectively (95%CI of differences 0.3 0 to
0. 76, P<0.05) . The length of hospital stay was shorterin AS-AQ
group than in the AS-SP group, at 5.01 (SD 1.22) versus 6.04
(SD 0.98) days, respectively (95%CI of differences 0. 71 to 1.35,
P < 0.05). However, there was no statistically significant difference
in fever clearance time between the groups.
Conclusion AS-AQ combination therapy reduces parasite
clearance time and length of hospital stay compared to AS-SP
46 â€¢ Paediatrlndones, Vol. 54, No. 1, January 2014
combination therapy in children with uncomplicated falciparum
malaria.

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