Treatment of Acute Urinary Tract Infection in Children with Pipemidic Acid

  • Lydia Kosnadi Department of Child Health, Universitas Diponegoro Medical School/Dr. Kariadi Hospital, Semarang, Central Java
  • Rochmanadji Widayat Department of Child Health, Universitas Diponegoro Medical School/Dr. Kariadi Hospital, Semarang, Central Java
  • Dwi Wastoro Department of Child Health, Universitas Diponegoro Medical School/Dr. Kariadi Hospital, Semarang, Central Java
  • Ari Yunanto Department of Child Health, Universitas Diponegoro Medical School/Dr. Kariadi Hospital, Semarang, Central Java
  • Ristitiati Gunawan Department of Child Health, Universitas Diponegoro Medical School/Dr. Kariadi Hospital, Semarang, Central Java
DOI: https://doi.org/10.14238/pi29.11-12.1989.228-32
Keywords: acute urinary tract infection; pipedimic acid; guinolone; gram positive; gram negative; e. coli

Abstract

Urinary tract infection in children is still an important problem in uronephrology. The disease.tends to develop recurrently and results in chronic progressive renal disease in the future.

Pipemidic acid is a bactericidal quinolone derivate, with a wide spectrum against gram positive and negative bacteria. Compared with nalidixic acid, pipemidic acid proves to be more effective against Pseudomonas, E. coli, Alkali genes and Salmonella.

Thirty one cases with acute urinary tract infection had been studied descriptively. The etiology revealed as follows: E. coli (45.2%), Alkaligenes (16.2%), Enterobacter (9.6%), Staphylococcus (9.6%), Pseudomonas (9.6%), Paracolon (6,5%), and Proteus (3.3%).

Pipemidic acid was administered orally to these patients, 15-20 mg/kg/day divided in 2 equal doses for 10 days. Bacteriological examinations was repeated on the 6th day and 11th day treatment. The result revealed that on the 6th day of treatment, in 27 patients (87, 09%) there was no bacteriuria while on the 11th  day the urine of 29 patients (93.54%) were sterile.

In conclusion, a 5 day treatment of acute urinary tract infection in children with pipemidic acid is quite effective.

References

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Published
2018-08-16
How to Cite
1.
Kosnadi L, Widayat R, Wastoro D, Yunanto A, Gunawan R. Treatment of Acute Urinary Tract Infection in Children with Pipemidic Acid. PI [Internet]. 16Aug.2018 [cited 6Feb.2025];29(11-12):228-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1948
Issue
Vol 29 No 11-12 (1989): November - December 1989
Section
Pediatric Nephrology

Copyright (c) 2018 Lydia Kosnadi, Rochmanadji Widayat, Dwi Wastoro, Ari Yunanto, Ristitiati Gunawan

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Received 2018-08-16
Published 2018-08-16