The Influence of Desensitization on The Recovery of Allergy, In articular Asthma

M. P. Damanik; A. Samik Wahab; Suminta Suminta; Ediyono Ediyono; Ismangoen Ismangoen

M. P. Damanik Department of Child Health, Universitas Gadjah Mada Medical School/Dr. Sardjito Hospital, Yogyakarta, Central Java
A. Samik Wahab Department of Child Health, Universitas Gadjah Mada Medical School/Dr. Sardjito Hospital, Yogyakarta, Central Java
Suminta Suminta Department of Child Health, Universitas Gadjah Mada Medical School/Dr. Sardjito Hospital, Yogyakarta, Central Java
Ediyono Ediyono Department of Child Health, Universitas Gadjah Mada Medical School/Dr. Sardjito Hospital, Yogyakarta, Central Java
Ismangoen Ismangoen Department of Child Health, Universitas Gadjah Mada Medical School/Dr. Sardjito Hospital, Yogyakarta, Central Java

Keywords: desensitization; allergy; intracutaneous skin test;

Abstract

An evaluation was carried out to determine the effect of desensitization on 62 asthmatic patients under the age of 14 years.

Preceeding the evaluation, an intracutaneous skin test was conducted of which all patients produced positive reactions to one or more allergen types.

Desensitization was carried out for at least 5 months (up to the 30th injection), .with the following results : good, 45 (72,57%); decreased symptoms 12 ( 19.03%), and constant (no change), 5 (8,4%).

All patients reached the maximum dosage ( 1 cc ), except 2 patients whom, given the maximum dosage, become worse, therefore suitable dosages were maintained (0.5 - 0. 7 cc).

Therapy for one type of allergen was also proven as follows: house dust, good 1 (100%); mite, good 1 (100%); bacteria, good 14 (87.5%), fungi, good 1 (100%). Result of therapy for 2 types of allergen : f' , use dust +splinter of human dunder in 31 patients was : good 24 (77.4%); constant 7 (22.59%). Whilst therapy for 3 types of allergen : house dust + splinter of human dunder + mite revealed : good, 4 (33.4%); decreased symptoms, 3 (25%); and constant, 5 (41.6%).

It may therefore be concluded that the greater the number of allergens, the less effective the desensitization becomes.

References

1. BELLANTI, J.A. : Immunology (Saunders, lgaku Shain, Tokyo 1971).
2. BRUUN, E. : Control Examination of the Specifity of specific desensitization in asthma. Acta Allerg. ( 2 : 122 (1949).
3. BRUUN, E. : Specific hyposensitization. in : New Concepts in allergy and clinical immunology. pp. 365- 369 (1971).
4. COCA, A. l : COOKE, R.A. : On the classification of the phenomenon of hypersensitiveness. J. Immunol 8: 163 (1923).
5. DEAMER, W.C. Injection therapy for asthma and allergic rhinitis. Pediat Clin. N. Am. 16 : 243 (1969).
6. FREEMAN, J. Further observations on the treatment of hay fever by hypordermic inoculation of pollen vaccine. Lancet ii : 814 (1911).
7. GODFREY, S. : Problem peculiar to diagnosis and management of asthma in children. Brit. Thor. Tubercul. Ass. Rev. 4 : 1 â€“ 16 (1974 ).
8. JOHN STONE, D .. E.; CRUMP, L. : Value of hyposensitization therapy for perennial bronchial asthma in children. Pediatrics 27: 396 (1961).
9. KLINE, A.H.; WAITE, C. :An evaluation of hyposensitization in childhood allergy. Ann. Allergy 18 : 80 (1960).
10. MELAN, H.L. : Principles of immunology management of allergic diseases due to extrinsic antigenic antigens; in Allergic diseases diagnosis and management. pp. 195 - 304 (1972).