Pediatric infective endocarditis initially presenting as hemorrhagic stroke

  • Emir Yonas Universitas YARSI Medical School, Jakarta
  • Raymond Pranata Universitas Pelita Harapan Medical School, Jakarta
  • Vito Damay Universitas Pelita Harapan Medical School, Jakarta
  • Nuvi Nusarintowati Department of Child Health, Universitas Indonesia Medical School/Dr. CIpto Mangunkusumo Hospital, Jakarta
Keywords: endocarditis; aneurysm; stroke

Abstract

Infective endocarditis refers to infection of the heart valves. While its incidence is low, it may cause serious complications. Despite advances in its management and diagnosis, this condition still retains high mortality and significant morbidity. Considerable controversy remains regarding antimicrobial prophylaxis to prevent infective endocarditis in patients with congenital heart disease. Neurologic complications are the second most common complication in patients with infective endocarditis, occurring in approximately 33% of cases.1 These include encephalopathy, meningitis, stroke, brain abscess, cerebral hemorrhage, and seizures. The vegetation formed as a consequence of endocarditis may dislodge and cause embolization. Vegetation size alone is an unreliable marker for embolization risk, however, size, in addition to location, mobility, infecting agent, and presence of antiphospholipid antibodies have the potential to be prognostic markers. The brain is the most frequent site of embolization. Furthermore, advances in medical approaches have resulted in an increase of patients at risk of endocarditis due to the now common and widely available indwelling intravascular approaches in medicine. In this report, we present a case of infective endocarditis in a child first presenting with hemorrhagic stroke.1,2

References

Paterick TE, Paterick TJ, Nishimura RA, Steckelberg JM. Complexity and subtlety of infective endocarditis. Mayo Clin Proc. 2007;82:615-21. DOI: 10.4065/82.5.615.

Hitzeroth J, Beckett N, Ntuli P. An approach to a patient with infective endocarditis. S Afr Med J.2016;106:145-50. DOI: 10.7196/samj.2016.v106i2.10327.

Wilson W, Taubert KA, Gewitz M, Lockhart PB, Baddour LM, Levison M, et al. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation. 2007;116:1736-54. DOI: 10.1161/CIRCULATIONAHA.106.183095.

Cancan Gursul N, Vadar I, Demirdal T, Gursul E, Ural S, Yesil M. Clinical and microbiological findings of infective endocarditis. J Infect Dev Ctries. 2016;10:478-87. DOI: 10.3855/jidc.7516.

Silverman ME, Upshaw CB. Extracardiac manifestations of infective endocarditis and their historical descriptions. Am J Cardiol. DOI: 10.1016/j.amjcard.2007.07.0342007;100:1802-7.

Fowler VG, Miro JM, Hoen B, Cabell CH, Abrutyn E, Rubinstein E, et al. Staphylococcus aureus endocarditis: a consequence of medical progress. JAMA. 2005;293:3012-21. DOI: 10.1001/jama.293.24.3012

Sparks SE, Thom CD. Acute pediatric stroke—what’s the hurry? A case for emergency physician-performed echocardiography. Am J Emerg Med. 2014;32:1440. DOI: 10.1016/j.ajem.2014.04.023.

Tomsic A. Li WWL, van Paridon M, Bindraban NR, de Mol BAJM. Infective endocarditis of the aortic valve with anterior mitral valve leaflet aneurysm. Tex Heart Inst J. 2016; 43: 345-9. DOI: 10.14503/THIJ-15-5322.

Molnar A, Sacui D, Manole S, Radulescu A, Beyer R. The value of transthoracic and transesophageal echocardiography for the diagnosis of the native aortic infective endocarditis valve complications: a case report and literature review. Med Ultrason. 2016;18:253-6. DOI: 10.11152/mu.2013.2066.182.ttr.

Kin H, Yoshioka K, Kawazoe K, Mukaida M, Kamada T, Mitsunaga Y, et al. Management of infectious endocarditis with mycotic aneurysm evaluated by brain magnetic resonance imaging. Eur J Cardiothorac Surg. 2013;44:924-30. DOI: 10.1093/ejcts/ezt101.

Miura T, Eishi K. Current treatment of active infective endocarditis with brain complications. Gen Thorac Cardiovasc Surg. 2013;61:551-9. DOI: 10.1007/s11748-013-0241-5.

Meshaal MS, Kassem HH, Samir A, Zakaria A, Baghdady Y, Rizk HH. Impact of routine cerebral CT angiography on treatment decisions in infective endocarditis. PLoS One. 2015;10:e0118616. DOI: 10.1371/journal.pone.0118616.

Peters PJ, Harrison T, Lennox JL. A dangerous dilemma: management of infectious intracranial aneurysms complicating endocarditis. Lancet Infect Dis. 2006;6:742-8. DOI: 10.1016/S1473-3099(06)70631-4.

Ducruet AF, Hickman ZL, Zacharia BE, Narula R, Grobelny BT, Gorski J, et al. Intracranial infectious aneurysms: a comprehensive review. Neurosurg Rev. 2010;33:37-46. DOI: 10.1007/s10143-009-0233-1.

Raoult D, Casalta JP, Richet H, Khan M, Bernit E, Rovery C, et al. Contribution of systematic serological testing in diagnosis of infective endocarditis. J Clin Microbiol. 2005;43:5238-42. DOI: 10.1128/JCM.43.10.5238-5242.2005.

Hoen B, Selton-Suty C, Lacassin F, Etienne J, Briançon S, Leport C, et al. Infective endocarditis in patients with negative blood cultures: analysis of 88 cases from a one-year nationwide survey in France. Clin Infect Dis. 1995;20:501-6. DOI: 10.1093/clinids/20.3.501.

Werner M, Andersson R, Olaison L, Hogevik H. A clinical study of culture-negative endocarditis. Medicine (Baltimore). 2003;82:263-73. DOI: 10.1097/01.md.0000085056.63483.d2.

Lamas CC, Fournier PE, Zappa M, Brandão TJ, Januà rio-da-Silva CA, Correia MG, et al. Diagnosis of blood culture-negative endocarditis and clinical comparison between blood culture-negative and blood culture-positive cases. Infection. 2016;44:459-66. DOI: 10.1007/s15010-015-0863-x.

Gupta S, Sakhuja A, McGrath E, Asmar B. Trends, microbiology, and outcomes of infective endocarditis in children during 2000-2010 in the United States. Congenit Heart Dis. 2017;12:196-201. DOI: 10.1111/chd.12425.

Daher AH, Berkowitz FE. Infective endocarditis in neonates. Clin Pediatr (Phila). 1995;34:198-206. DOI: 10.1177/000992289503400405.

Sun LC, Lai CC, Wang CY, Wang YH, Wang JY, Hsu YL, et al. Risk factors for infective endocarditis in children with congenital heart diseases - a nationwide population-based case control study. Int J Cardiol. 2017;248:126-30. DOI: 10.1016/j.ijcard.2017.08.009.

Published
2020-04-28
How to Cite
1.
Yonas E, Pranata R, Damay V, Nusarintowati N. Pediatric infective endocarditis initially presenting as hemorrhagic stroke. PI [Internet]. 28Apr.2020 [cited 31Oct.2024];60(3):167-2. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1882
Section
Case Report
Received 2018-06-08
Accepted 2020-04-28
Published 2020-04-28