Captopril Treatment in Rheumatic Heart Disease with Congestive Heart Failure A Preliminary Report

  • Hardiman Sastrosubroto Division of Paediatric Cardiology, Department of Child Health, Medical Faculty, Diponegoro University/Dr. Kariadi Hospital, Semarang
  • Santosa Soeroso Division of Paediatric Cardiology, Department of Child Health, Medical Faculty, Diponegoro University/Dr. Kariadi Hospital, Semarang
  • Eriyati Indrasanto Division of Paediatric Cardiology, Department of Child Health, Medical Faculty, Diponegoro University/Dr. Kariadi Hospital, Semarang
DOI: https://doi.org/10.14238/pi29.9-10.1989.209-14
Keywords: captopril; ace inhibitor; rheumatic heart diasease; congestive heart failure

Abstract

A small scale controlled trial of captopril (ACE inhibitor) was conducted in 8 children with congestive heart failure due to rheumatic mitral regurgitation with or without mild mitral stenosis. The age of the patient ranged from 5.5 to 13 years (mean 9,3 years). Four children, served as control group, received digitalis and diuretics as standard treatment; while the other 4 children also received 2 x 12,5 mg of captopril in addition to standard treatment. The effect of both regimens were measured by using
changes of left ventricular function as seen on the echocardiogram performed before treatment, and then 3, 7 and 14 days thereafter.


Definite conclusion cannot be made because of the small number of patients; but it is apparent that some improvements of left ventricular functions in the captopril group were more evident when compared with that of the control group of standard treatment.
Side effects of captopri/ were not found.

References

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4. FRIEDMAN, W.F., GEORGE, B.L.: Treatment of congestive heart failure by altering loading condition of the heart. J. Pediat. 106 : 697 (1985).
5. MASON, E.T.: Introduction to recent advances in pathogenesis and management of congestive heart failure; in Mason, D.T., Ed. Congestive Heart Failure; pp. 1-9, (Yorke, New York, Philadelphia 1976)
6. MEYER, R.A.: Pediatric Echocardiography; pp. 257-79, (Lea & Febiger 1977).
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Published
2018-03-20
How to Cite
1.
Sastrosubroto H, Soeroso S, Indrasanto E. Captopril Treatment in Rheumatic Heart Disease with Congestive Heart Failure A Preliminary Report. PI [Internet]. 20Mar.2018 [cited 6Feb.2025];29(9-10):209-4. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1852
Issue
Vol 29 No 9-10 (1989): September - October 1989
Section
Articles

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Received 2018-05-09
Published 2018-03-20