Liver function in children with human immunodeficiency virus infection before and after 6 months of highly active antiretroviral therapy

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Eva Jacomina Jemima Sapulete
I Gusti Ngurah Sanjaya Putra
Ketut Dewi Kumara Wati
Hendra Santoso
I Putu Gede Karyana
Komang Ayu Witarini
Ni Nyoman Metriani Nesa


Background Highly active antiretroviral therapy (HAART) has resulted in dramatic decreases in morbidity and improved survival rate in human immunodeficiency virus (HIV)-infected patients. Although the risk of morbidity has decreased, it has been replaced by other long-term complications, such as hepatotoxicity. Hepatotoxicity is often reflected in biochemical abnormalities of liver function, such as elevated levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and aspartate aminotransferase-to-platelet ratio index (APRI).

Objective To compare liver function spectrum (AST, ALT, and APRI) in HIV-infected children before and after at least 6 months of HAART.

Methods This observational study (before and after) was conducted in pediatric patients with HIV infection who received HAART for at least 6 months at Sanglah Hospital, Denpasar. Data were collected from medical records.

Results Forty-nine patients were observed in this study. The mean AST, ALT, and APRI levels before HAART were higher than after at least 6 months of HAART. Anti-tuberculosis treatment and fluconazole therapy were not confounding factors for AST, ALT, and APRI.

Conclusion Liver function spectrum enzyme levels of AST, ALT, and APRI are improved after at least 6 months of HAART.

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How to Cite
Sapulete E, Sanjaya Putra IGN, Kumara Wati K, Santoso H, Karyana IPG, Witarini KA, Metriani Nesa NN. Liver function in children with human immunodeficiency virus infection before and after 6 months of highly active antiretroviral therapy. PI [Internet]. 27Jul.2018 [cited 26May2019];58(4):159-4. Available from:
Received 2018-02-27
Accepted 2018-06-28
Published 2018-07-27


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