Diabetes duration and thyroid stimulating hormone levels in children with type 1 diabetes mellitus

Main Article Content

Nur Rochmah
Muhammad Faizi

Abstract

Background Children with type 1 diabetes mellitus (T1DM) are at risk of thyroid dysfunction. An association between diabetes duration and thyroid stimulating hormone level remains inconclusive.

Objective To assess for a possible association between diabetes duration and thyroid stimulating hormone levels in children with T1DM.

Methods We conducted a cross-sectional study from January to June 2017 in the Pediatric Endocrine Outpatient Clinic at Dr. Soetomo Hospital. Subjects were children with T1DM aged 7 to <18 years. Exclusion criteria were children with diabetic ketoacidosis, previously diagnosed thyroid problems, and hospitalization in the pediatric intensive care unit (PICU). 

Results From the 55 regular patients in our outpatient clinic, 34 patients were included in the study. Nineteen (54.3%) subjects were male, and the overall mean age was 11.3 years. Subjects’ mean duration of diabetes was 3 years and their mean thyroid stimulating hormone concentration was 3.76mIU/L. Pearson’s correlation test revealed no significant association between duration of diabetes and thyroid stimulating hormone level (rs=-0.068; P=0.703).

Conclusion There is no significant association between duration of diabetes and thyroid stimulating hormone levels in children with T1DM. 

Article Details

How to Cite
1.
Rochmah N, Faizi M. Diabetes duration and thyroid stimulating hormone levels in children with type 1 diabetes mellitus. PI [Internet]. 30Apr.2018 [cited 27May2018];58(2):80-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1760
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References

1. World Health Organization. Global report on diabetes. Geneva: WHO; 2016. p.21
2. International Diabetes Federation (IDF). Diabetes atlas. 7th ed. Belgium: International Diabetes Federation; 2015. [cited: 2017, June 2nd. Available from: http: //www.idf.org/diabetesatlas.
3. UKK Endokrin Anak. Unpublished data. 2016.
4. Krzewska A, Ben-Skowronek I. Effect of associated autoimmune diseases on type 1 diabetes mellitus incidence and metabolic control in children and adolescents. BioMed Res Int. 2016;2016:6219730.
5. Jonsdottir B, Anderson C, Carlson A, Delli A, Forsander G, Ludvigsson J, et al. Thyroid autoimmunity in relation to islet autoantibodies and HLA-DQ genotype in newly diagnosed type 1 diabetes in children and adolescents. Diabetologia. 2013;56:1735-42.
6. Denzer C, Karges B, Näke A, et al. Subclinical hypothyroidism and dyslipidemia in children and adolescents with type 1 diabetes mellitus. Eur J Endocrinol. 2013;168:601–8.
7. Ghawil M, Tonutti E, Abusrewil S, et al. Autoimmune thyroid disease in Libyan children and young adults with type 1 diabetes mellitus. Eur J Pediatr. 2011;170:983–7.
8. Van den Driessche A, Eenkhoorn V, Van Gaal L, De Block C. Type 1 diabetes and autoimmune polyglandular syndrome: a clinical review. Neth J Med. 2009 67:376–87.
9. Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease prevalence study. Arch Intern Med. 2000;160:526-34.
10. Wu T, Flowers JW, Tudiver F, Wilson JL, Punyasavatsut N. Subclinical thyroid disorders and cognitive performance among adolescents in the United States. BMC Pediatr. 2006;6:12.
11. Kordonouri O, Hartmann R, Deiss D, Wilms M, Grüters-Kieslich A. Natural course of autoimmune thyroiditis in type 1 diabetes: association with gender, age, diabetes duration, and puberty. Arch Dis Child. 2005;90:411-4.
12. De Boer, Lafranchi SH, 2007. Pediatric thyroid testing issues. Pediatr Endocrinol Rev, 5;1:570-7. In: Kappy MS, Allen DB, Geffner ME. Pediatric practice endocrinology.2010: 107-30.
13. Kordonouri O, Klingensmith G, Knip M, Holl RW, Menon PSN, Aanstoot HJ, et al Other complications and diabetes-associated conditions in children and adolescents.Pediatric Diabetes 2014: 15 (Suppl. 20): 270–8.
14. Umpierrez GE, Latif KA, Murphy MB, et al. Thyroid dysfunction in patients with type 1 diabetes: A longitudinal study. Diabetes Care. 2003;26:1181–5.
15. Severinski S, Banac S, Severinski NS, Ahel V, Cvijovic K. Epidemiology and clinical characteristics of thyroid dysfunction in children and adolescents with type 1 diabetes. Coll Antropol. 2009;33:273–9.
16. Glastras SJ, Craig ME, Verge CF, et.al. The role of autoimmunity at diagnosis of type 1 diabetes in the development of thyroid and celiac disease and microvascular complications. Diabetes Care. 2005;28:2170-5.
17. Kim EY, Shin HC, Yang SW. Polymorphisms of HLA class II predispose children and adolescent with type 1 diabetes mellitus to autoimmune thyroid disease. Autoimmunity. 2003;36:177-81.
18. Warncke K, Frohlich-Reiterer EE, Thon A, et al. Polyendocrinopathy in children, adolescents, and young adults with type 1 diabetes: a multicenter analysis of 28,671 patients from the German/Austrian DPV-Wiss database. Diabetes Care. 2010;33:201-7.
19. Barker JM, Yu J, Yu L, Wang J, Miao D, Bao F, et al. Autoantibody “subspecificity” in type 1 diabetes: risk for organ-specific autoimmunity clusters in distinct groups. Diabetes Care. 2005; 28:850–5.
20. Sharifi F, Ghasemi L, Mousavinasab N. Thyroid function and anti-thyroid antibodies in Iranian patients with type 1 diabetes mellitus: influences of age and sex. Iran J Allergy Asthma Immunol. 2008;7:31–6.
21. Araujo J, Brandão LAC, Guimarães RL, et al. Prevalence of autoimmune thyroid disease and thyroid dysfunction in young Brazilian patients with type 1 diabetes. Pediatr Diabetes. 2008;9:272–6.
22. Shun CB, Donaghue KC, Phelan H, Twigg SM, Craig ME. Thyroid autoimmunity in type 1 diabetes: systematic review and meta-analysis. Diabet Med. 2014;31:126–35.
23. Lee YJ, Jung SY, Jung HW, et al. Unfavorable course of subclinical hypothyroidism in children with Hashimoto’s thyroiditis compared to those with isolated non-autoimmune hyperthyrotropinemia. J Korean Med Sci. 2017;32:124-9.
24. Kakleas K, Paschali E , Kefalas N, et al. Factors for thyroid autoimmunity in children and adolescents with type 1 diabetes mellitus. J Med Sci. 2009;114:214–20.
25. Kordonouri O, Klinghammer A, Lang EB, et al. Thyroid autoimmunity in children and adolescents with type 1 diabetes: a multicenter survey. Diabetes Care. 2002;25:8:1346-50.
26. Kakleas K, Soldatou A, Karachaliou F, Karavanaki K. Associated autoimmune diseases in children and adolescents with type 1 diabetes mellitus (T1DM). Autoimmun Rev. 2015;14;781-97.
27. Muhame RM, Mworozi EA, Ma Assey K. Thyroid autoimmunity and function among Ugandan children and adolescents with type-1 diabetes mellitus. Pan Afr Med J. 2014;19:137.
28. Ramasamy V, Kadiyala R, Fayyaz F, Mallipedhi A, Baglioni P, Okosieme OE. Value of baseline serum thyrotropin as a predictor of hypothyroidism in patients with diabetes mellitus. Endocr Pract. 2011;17:26-32.
29. Stockigt J. Case finding and screening strategies for thyroid dysfunction. Clin Chim Acta. 2002;315:111–24.