Risk factors of respiratory allergy in children with atopic dermatitis
Keywords:
respiratory allergy, allergy, atopic dermatitis, asthma, allergic rhinitis
Abstract
This paper described a case-control study among atopic dermatitis (AD)patients on the development of respiratoric allergy (RA) i.e., (asthma and for allergic rhinitis), in Cipto Mangunkusumo Hospital, Jakarta. Secondary data were collected from January 1, 1995 to April31, 1998. One hundred and one children with RAin AD patients (case group), and 101 children with AD (control group) aged <16 years were evaluated for exposure to possible risk factors for RA. The mean age of AD onset was 1 year and 5 weeks in the case group, and 2 years and 2 months in the control group (p = 0.000). Early AD onset < 1 year was a significant risk factor (p = 0,0003; OR = 9.6, 95% confid ence intervals 2.8 ; 33.3). History of inhalant allergy was associated with the excess risk for RAin children with AD (p = 0.0025; OR 2.9, 95%C!: 1.5; 5.7). Early onset of egg supplementation <6 months was statistically significant to increase that such risk (p = 0.05; OR 3.3, 95%CI: 1.0 ; 11.7). Our findings suggest that early onset of AD before the age of one year would increase the development of RA Qn AD patients. Besides, we conclude that postponing the administration of egg supplementation until the age of one year, and preventing the exposure of inhalant aJlergens would prevent RA, particularly in family history of a topy.
References
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31. Nickel R, Kulig M, Forster J, Bergmann R, Bauer CP, Lau S. Sensitization to hen's egg at the age or twelve months is predictive for allergic sensitzation to common indoor and outdoor allergens at the age of three years. J Allergy Clin Immunol 1997; 99:613-7.
2. Bono J, Levitt P. Relationship of infantile atopic dermatitis to asthma and other respiratory allergies. Ann Allergy 1964; 22:72-80.
3. Leung DYM. Atopic dermatitis: the skin as window into the pathogenesis of chronic allergic diseases. J Allergy Clin Immunol 1995; 96:302-18.
4. Salob PS, Laverty A, Atherton DJ. Bronchial hyperresponsiveness in children with atopic dermatitis. Pediatrics 1 993; 91: 13-6.
5. Sherill D, Sears MR, Lebowitz MD, et al. The effects of airway hyperresponsiveness, wheezing, and atopy on longitudinal pulmonary function in children: a 6-year follow up study. Pediatr Pulmonol 1992; 13:78-85.
6 Braman SS. Lung function in allergic rhinitis. In: Settipane GA, ed. Rhinitis; 1st ed. New · England Society .of Allergy, 1984· 70-4 .
7. Tan BB, Weald D, Strickland d I, Friedmann PS. Double-blind controlled trial of effect of house dust-mite allergen avoidance on atopic dermatitis. Lancet 1996; 34 7: 15-8.
8. Arshad SH, Matthews S, Gant C, Hide OW. Effect of allergen avoidance on development of allergic disorders in infancy. Lancet 1992; 339:1493-7.
9. Etzel RA. Indoor air pollution and childhood asthma: effective environmental interventions. Environ Health Perspect 1995; 103:55-8.
10. Braun-Falco. Atopy and atopic eczema. In: Braun-Falco 0, Plewig G, WollfHH, Winkelmann RK, eds. Dermatology; 3rd ed. Berlin: Springger-Verlag, 1991; 346-57.
11. Tanaka M, Aiba S, Matsumura N, et al. IgE-mediated hypersensitivity and contact sensitivity to multiple environmental allergens in atopic dermatitis. Arch Dermatol 1994;
130: 1393-401.
12. Siregar SP. Konsep mutakhir patogenesis asma anak. Presented at: simposium penatalaksanaan mutakhir asma pada anak 23 November 1993. Jakarta: PPIKB/CME, 1993; 1-11.
13. Said M. Gambaran klinis dan diagnosis asma pada anak. In: Rahajoe N, Said M, Ghazali MV, eds. Beberapa masalah klinis praktis pulmonologi anak; PKB XVII October 21-22, 1988. Jakarta: Balai Pustaka FKUI, 1988; 61-79.
14. Hosmer OW, Lemeshow S. Model-building strategies and methods for logistic regression. In: Hosmer OW, Lemeshow S, eds. Applied logistic regression. New York: John Wiley & Sons, 1989; 82-134.
15. Pasternack. The prediction of asthma in infantile eczema: a statistical approach. J Pediatr 1965; 66: 164-5.
16. Rudzki E, Romanski B. Clinical characterization of asthma-prurigo" syndrome with emphasis on risk factors (Abstract). Pneumol Alergol Pol 1994; 62:397-404.
17. Guillet G, Guillet MH. Natural history of sensitizations in atopic dermatitis. Arch Dermatol 1992; 128:187-92.
18. Zeiger RS, Heller S. The development and prediction of atopy in high risk children: follow up at age seven years in a prospective randomized study of combined maternal and infant food allergen avoidance. J Allergy Clin lrnmunol 1995; 95: 1179-90.
19. Horwood W, Fergusson OM, Hons BA, Shannon FT. Social and familial factors in the development of early childhood asthma. Pediatr 1985; 75:859-68.
20. Cuijpers CE, Swaen GM, Wesseling G, S~rm~s F, Wouters EJ:<. Adverse effects of the indoor environment on respiratory health m pnmary school children. Envrron Res 1 095; 68:11-23.
21. Anderson JA. Adverse reactions to foods. In: Bierman CW, Pearlman OS, eds. Allergenic diseases from infancy to adulthood; 2nd ed. Philadelphia: Saunders, 1988; 130-40.
22. Lindfors A Wickman M Hedlin G, Pershagen G, Rietz H, Nordvall SL. Indoor environmental risk factors in young asthmatics: a case-control study. Arch Dis Child 1995; 73:408-12.
23. Mygind N. The gastro-intestinal tract and immunology. In: Mygind N, ed. Essential allergy; lsted. Oxford: Blackwell, 1986; 137-41.
24. Le-Roux P, Bourderont D, Loisel I, Collet A, Boulloche J, Briquet MT. Epidemiology of infantile asthma in the Le Havre region. Arch Pediatr 1995; 2:643-9.
25. Bener A, Galadari I, Naser KA. Pets, allergy and respiratory symptoms in children living I in a desert country (Abstract). Allerg Immunol Paris 1995; 27: I 90-5.
26. Abdulrazzac YM, Bener A, DeBuse P. Pet ownership in the UAE: its effect on a llergy and respiratory symptoms. J Asthma I 995; 32: l I 7-24.
27. Wahn U, Susanne L, Bergmann R, Kulig M, Forster J, Bergmann I. Indoor allergen exposure is a risk factor for sensitization during the ftrst three years of life. J Allergy Clin Immnunol 1997; 99:763-9.
28. Sorva R, Makinen-Kiljunen S, Juntunen-Badanan K. Immunodeficiency and other clinical immunology: -Lactoglobulin secretion in human milk varies widely after cows milk ingestion
in mothers of infants with cow's milk allergy. J Allergy Clin lmmunol 1 994; 93:787-92.
29. Savilahti E, Tainio V-M, Salmenpera L, Sumes MA, Perheentupa J . Prolonged exclusive breast feeding and heredity as determinants in infantile atopy. Arch Dis Child I 987; 62:269-73.
30. Halpern SR, Sellars WA, Johnson RB, Anderson DW, Saperstein S, Reisch JS. Development of childhood allergy in infants fed breast, soy, or cow milk. J Allergy Clin Immunol 1973; 51:139-51.
31. Nickel R, Kulig M, Forster J, Bergmann R, Bauer CP, Lau S. Sensitization to hen's egg at the age or twelve months is predictive for allergic sensitzation to common indoor and outdoor allergens at the age of three years. J Allergy Clin Immunol 1997; 99:613-7.
Published
1999-06-30
How to Cite
1.
Siregar S, Madiyono B, Adisasmito A. Risk factors of respiratory allergy in children with atopic dermatitis. PI [Internet]. 30Jun.1999 [cited 25Apr.2024];39(5-6):134-4. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1689
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Received 2017-11-17
Accepted 2017-11-17
Published 1999-06-30
Accepted 2017-11-17
Published 1999-06-30
