Effect of carnitine in diphtheria: A preliminary report
Keywords:
carnitine, diphtheria, CK-MB level, diphtheritic myocarditis
Abstract
A double placebo controlled trial was conducted on 68 diphtheriapatients who were hospitalized in pediatric ward of Kariadi Hospital, Semarang, from 1 April 1990 to 31 March 1991. The age range of the patients was between 7 months to 13 years, with the median of 48 months and the mean of 60.5 (SD 11) months. The pretreatment
characteristics of both groups were similar with respect to sex, the clinical condition on admission, presence of bullneck, nutritional and immunization status. Oral camitine was administered with a dose of 100 mg/kg/ day divided into 3 doses. Other standard treatment was administered to all patients. Post-treatment comparisons were performed on the prevalence of myocarditis, CK-MB level examined on the fifth day of treatment, and mortality. It was found that the prevalence of myocarditis and CK-MB levels' were significantly less than those in the placebo group, while the mortality in the carnitine group (3%) although smaller than in placebo group (17%) was not statistically different. It seems that 1-camitine is useful to prevent diphtheritic myocarditis,
while its effect on improving the overall prognosis needs further study.
References
1. Krugman S, Kats SL. Infectious diseases of children, 7th eel. St. Louis, 1981:13-24.
2. Feigin RD. Diphtheria. In: Nelson textbook of pediatrics 12th ed. Tokyo (Gaku-Shoin) Saunders, 1983:641-4.
3. Wittels B., Bressler. R. Biochemical lesion of diphtheria toxin in the heart. J Clin Invest. 1964; 43:630-7.
4. Ramos ACMF, Elias PRP, Barrucand L, Da Silva JAF. The protective effect of camitine in human diphtheric myocarditis. Pediatric Research 1984; 18:815-9.
5. Challoner DM, Mandelbaum I, Eliott W. Protective effect of I camitine in experimental intoxication with diphtheria toxin. J Lab Clin Med 1971; 77: 616-28.
6. Santoso S. Aspek klinis dan komplikasi difteri pada anak. Dalam: Penyakit infeksi PBIKA Semarang, 1986: 73-89.
2. Feigin RD. Diphtheria. In: Nelson textbook of pediatrics 12th ed. Tokyo (Gaku-Shoin) Saunders, 1983:641-4.
3. Wittels B., Bressler. R. Biochemical lesion of diphtheria toxin in the heart. J Clin Invest. 1964; 43:630-7.
4. Ramos ACMF, Elias PRP, Barrucand L, Da Silva JAF. The protective effect of camitine in human diphtheric myocarditis. Pediatric Research 1984; 18:815-9.
5. Challoner DM, Mandelbaum I, Eliott W. Protective effect of I camitine in experimental intoxication with diphtheria toxin. J Lab Clin Med 1971; 77: 616-28.
6. Santoso S. Aspek klinis dan komplikasi difteri pada anak. Dalam: Penyakit infeksi PBIKA Semarang, 1986: 73-89.
Published
1999-04-30
How to Cite
1.
Soetono S, Soeroso S, Sutikno W. Effect of carnitine in diphtheria: A preliminary report. PI [Internet]. 30Apr.1999 [cited 15Nov.2024];39(3-4):102-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1685
Section
Infection & Tropical Pediatrics
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Received 2017-11-16
Accepted 2017-11-16
Published 1999-04-30
Accepted 2017-11-16
Published 1999-04-30
