Thrombospondin-1 and blood pressure in 7-8-year-old children born low birth weight and small for gestational age

Main Article Content

Marlyn Malonda
Adrian Umboh
Stefanus Gunawan


Background Thrombospondin-1 (TSP-1) is associated with endothelial damage, glomerular impairment, and hypertension. Low birth weight (LBW) and small for gestational age (SGA) children have higher risk of morbidity and mortality.

Objective To assess for a possible association between TSP-1 level and blood pressure in children who were born low birth weight and small for gestational age.

Methods We conducted a cross-sectional study from March to May 2015. Inclusion criteria were children who were born LBW and SGA in 2007-2008 at Prof. Dr. R. D. Kandou General Hospital, resided in Manado, North Sulawesi, had complete medical records, and whose parents consented to their participation. Exclusion criteria were children who were in puberty, obese, had renal disease, taking medications that affect blood pressure, or who were admitted to the hospital in the 2 weeks prior to enrollment.  Data were analyzed using regression and simple correlation tests to assess for associations between TSP-1 and birth weight, as well as TSP-1 and blood pressure.

Results Subjects’ mean TSP-1 level was 257.95 ng/dL. There was a strong negative correlation between TSP-1 and birth weight (r=-0.784; P<0.0001). In addition, there were strong positive correlations between TSP-1 level and systolic blood pressure (r=0.718; P<0.0001) as well as TSP-1 and diastolic blood pressure (r=0.670; P<0.0001).

Conclusion Higher TSP-1 is associated with higher systolic and diastolic blood pressure in 7-8-year-old children who were LBW and SGA at birth. Also, TSP-1 and birth weight have a strong negative correlation.

Article Details

How to Cite
Malonda M, Umboh A, Gunawan S. Thrombospondin-1 and blood pressure in 7-8-year-old children born low birth weight and small for gestational age. PI [Internet]. 5Jan.2018 [cited 18Jan.2020];57(5):269-3. Available from:
Received 2017-10-13
Accepted 2017-10-31
Published 2018-01-05


1. Goldenberg RL, Culhane JF. Low birth weight in the United States. Am J Clin Nutr. 2007;85:584-90.
2. Villar J, Belizan JM. The relative contribution of prematurity and fetal growth retardation to low birth weight in developing and developed societies. Am J Obstet Gynecol. 1982;143:793-8.
3. Wardlaw T, Blanc A, Zupan J, Ahman E. Low birthweight: country, regional and global estimates. Geneva: WHO Publications; 2004. p.5-6.
4. Gunardi H. Pemantauan bayi prematur. In: Trihono PP, Purnamawati S, Sjarif DR, Hegar B, Gunardi H, Oswari H, editors. Hot topics in pediatrics II. Naskah lengkap Pendidikan Kedokteran Berkelanjutan Ilmu Kesehatan Anak XLV; 2002 Feb 18-19; Jakarta: Balai Penerbit FKUI; 2002. p. 17-27.
5. Hartanto S, Mustadjab I. Profil bayi berat lahir rendah di ruang perinatology RSUP Manado. Batam: Proceedings from the PIT IKA 11-IDAI; 2004 Jul 12-14; 2004. p. 42.
6. Barker DJ. The developmental origins of adult disease. J Am Coll Nutr. 2004;23:588-95.
7. Isenberg JS, Wink DA, Roberts DD. Thrombospondin-1 antagonizes nitric oxide-stimulated vascular smooth muscle cell responses. Cardiovasc Res. 2006;71;785-93.
8. Bauer EM, Qin Y, Miller T, Bandle R, Csanyi G, Pagano PJ, et al. Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation. Cardiovasc Res. 2010;88:471-81.
9. Isenberg JS, Qin Y, Maxhimer JB, Sipes J, Despres D, Schnermann J, et al. Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress. Matrix Biol. 2009;28:110-19.
10. Lopez-Dee Z, Pidcock K, Gutierrez LS. Thrombospondin 1: multiple paths to inflammation. Mediators Inflamm. 2011:1-10.
11. Vanhoutte D, Heyman S. Thrombospondin 1: A protective “matric-cellular” signal in the stressed heart. J Hypertens. 2011;58:770-1.
12. Murphy-Ullrich JE, Sage EH. Revisting the matricellular concept. Matrix Biol. 2014;37:1-14.
13. Soto-Pantoja DR, Shih HB, Maxhimer JB, Cook KL, Ghosh A, Isenberg JS, et al. Thrombospondin-1 and CD47 signaling regulate healing of thermal injury in mice. Matrix Biol. 2014;37:25-34.
14. Duquette M, Nadler M, Okuhara D, Thompson J, Shuttleworth, Lawler J. Members of the thrombospondin gene family bind stromal interaction molecule 1 and regulate calcium channel activity. Matrix Biol. 2014;37:15-24.
15. Rogers NM, Sharifi-Sanjani M, Csanyi G, Pagano PJ, Isenberg J. Thrombospondin-1 dan CD47 regulation of cardiac, pulmonary and vascular responses in health and disease. Matrix Biol. 2014;37:92-101.
16. Isenberg JS, Frazier WA, Roberts DD. Thrombospondin-1 is a central regulator of nitric oxide signaling in vascular physiology. Cell Mol Life Sci. 2008;65:728-42.
17. Andraweera PH, Dekker A, Thompson SD, North RA, McCowan ME, Roberts CT. A functional variant in the thrombospondin 1 gene and the risk of small for gestational age infants. J Thromb Haemost. 2011;9:2221-8.
18. Kang DH, Anderson S, Kim YG, Mazzalli M, Suga S, Jefferson A, et al. Impaired angiogenesis in the aging kidney: vascular endothelial growth factor and thrombospondin-1 in renal disease. Am J Kidney Dis. 2001;37:601-11.