Circulating Immune Complex in Glomerular Diseases

  • H. Alatas Department of Child Health, University of Indonesia, Jakarta
  • I. G. N. Wila Wirya Department of Child Health, University of Indonesia, Jakarta
  • Taralan Tambunan Department of Child Health, University of Indonesia, Jakarta
  • S. Cornain Department of Pathology, University of Indonesia, Jakarta
  • Sucahyo Sucahyo Department of Pathology, University of Indonesia, Jakarta
  • S. Himawan Department of Pathology, University of Indonesia, Jakarta
  • Gunardjono Gunardjono Department of Pathology, University of Indonesia, Jakarta
DOI: https://doi.org/10.14238/pi22.11-12.1982.211-6
Keywords: circulating immune complex, glomerular diseases, CIC, nephrotic syndrome, minimal lesion nephrotic syndrome

Abstract

Circulating Immune Complex (CIC) in the serum have been studied in 75
patients with glomerular diseases. The highest positive rate in patients with post streptococcal glomerulonephritis and lupus nephritis were respectively 83.3% atld 75%.

In nephrotic syndrome: 33.3% (5 jl5) was positive in diffuse mesangial proliferative cases, and in all 3 patient~· with membranoproliferative glomerulonephritis, membranous nephropathy and focal  glomerulosclerosis. All of them had detectable immune deposits in the glomeruli.


In minimal lesion nephrotic syndrome (MLNS) without glomerular immune
deposits, CIC was positive in 2 out of 17 cases (12%). This support the hypothesis that in MLNS a humoral immune mechanil'im might take part in the pathogenesis of the disease.

References

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Published
1982-12-31
How to Cite
1.
Alatas H, Wirya IGN, Tambunan T, Cornain S, Sucahyo S, Himawan S, Gunardjono G. Circulating Immune Complex in Glomerular Diseases. PI [Internet]. 31Dec.1982 [cited 6Feb.2025];22(11-12):211-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1636
Issue
Vol 22 No 11-12 (1982): November - December 1982
Section
Pediatric Nephrology

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Received 2017-08-29
Accepted 2017-08-29
Published 1982-12-31