Immunological Aspects of Persistent Hepatitis B in Children

  • Harsoyo Notoatmojo Department of Child Health, Medical School, Diponegoro University/Kariadi Hospital Semarang
DOI: https://doi.org/10.14238/pi38.9-10.1998.224-32
Keywords: immunological aspects, persistent Hepatitis B, children

Abstract

We studied the immunological status of 203 children having persistent Hepatitis B (positive HBsAg) ranging in age from 6 to 14 years in Semarang Municipality. All patients showed negative results of humoral immunity (IgM anti-HBc), excluding the possibility of acute hepatitis B (HB). Cellular immunity examination using CMI skin test showed positive result in 64.9% of persistent and 65.2%, ln non-persistent HB (p>0.05). T cell examination shows significant statistical difference (p<0.01) between persistent and non-persistent HB, and there was a significant difference (p<0.01) on CD4 cell examination; indicating a difference on immunoregulation function and response repression of anti-virus between the two groups. There was no significant differences on CD4/CD8 ratio between persistent and non-persistent HB. The specific function of cytotoxic T cell also shows no significant difference between the two groups.

References

Alberti A, Cavalletto D, Pontiso P, Chemello L, Tagariello G, Belussi F. Antibody response to Pre-S2 and hepatitis B induced liver damage. Lancet 1988; 1: 1421-3.

Alberti SA, Diana S, Eddleston ALWF, Scullard GH. Detection of a new antibody system reacting with Dane particles in hepatitis B virus infection. BMJ 1978; 2:1056-8.

Dientag JL. lmmunologic mechanism in chronic viral hepatitis. In: Vyas GN, Dientag JL, Hoofnagle JL, eds. Viral hepatitis and liver disease. Grune and Stratton lnc. New York, 1984;135-64.

Eddleston ALWF, Mondelli M, Mieli-Vergan IG, et al. Lymphocytes cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection. Hepatology 1982;2: 122S-127S.

Eddleston ALWF. Immunological aspects of hepatitis B infection. In: Zuckerman A, Allan R, eds. Viral hepatitis and liver diseases. New York: Liss Inc, 1988;603-5.

Kiyosawa K, Wada S, lmai Y, et al. Significance of IgM antibody to hepatitis B core antigen for the differential diagnosis of acute and chronic hepatitis B virus infection and for the evaluation of the inflammatory activity of type B chronic liver diseases. Gastroenterol Japon 1986; 21:6 .

Brunetto MR, Cerenzia MT, Oliveri F, et al. Monitoring the natural cause and response to therapy of chronic hepatitis B with an automated semi-quantitative assay for lgM antiHBc. J Hepatol 1993;19:431-6.

Barnaba W, Musca A, Cordova C, Levrero M, Ruocco G, Balsanof. Relationship between T cell subsets and supressor cell activity in chronic hepatitis B virus infection. Clin Exp Immunol 1983;53;281-8.

Neurath AR., Kent S.B.H., Strick N. The biological role of pre-S sequences in the hepatitis B Virus envelope protein: Implication for vaccine design. Proceeding of Asian Symposium on Strategies for Large Scale Hepatitis B Immunization. Hong Kong June 12-13, 1986;97- 112.

Stites DP, Terr AI. Basic and clinical immunology. Prentice-Hall Intern. Inc. USA 1991.

Dienfeng Z, Bangyuan L, Zuchong L and Fengsheng C. Cell-mediated immune response in viral hepatitis B. Chinese Med J 1980;2:90-97.

Dienstag JL. Immunologic mechanism in chronic viral hepatitis. In: Vyas GN, Dientag JL, Hoofnagle JH, eds. Viral hepatitis and liver disease. New York: Grune & Stratton, Inc. 1984.

Eddleston ALEF. Overview of RB pathogenesis. In: Hollinger FB, Lemon SM, Margolis H, eds. Viral hepatitis and liver disease. Baltimore: Williams & Wilkins, 1990.

Aoyama K, Kojima T, Inoue K, Sasaki H. Immunohistochemical investigation of hepatitis B virus associated antigen, HLA antigens and lymphocyte subsets in type B chronic hepatitis. Gastroenterol Japan 1990;25:41-53.

Mondelli M, Vergru GM, Alberti A, Vergani D, el al. Specificity of T lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection: evidence that T cells are directed against HBV core antigen expressed on hepatocytes. J Immunol 1982; 129:6.
Published
2017-07-11
How to Cite
1.
Notoatmojo H. Immunological Aspects of Persistent Hepatitis B in Children. PI [Internet]. 11Jul.2017 [cited 18Apr.2024];38(9-10):224-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1575
Issue
Vol 38 No 9-10 (1998): September - October 1998
Section
Articles

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Received 2017-07-10
Accepted 2017-07-10
Published 2017-07-11