The Treatment of Tuberculous Meningitis in Children with A Combination of Isoniazid, Rifampicin and Streptomycin (A preliminary report)

  • Nastitin Rahajoe Department of Child Health, Medical School, University of Indonesia, Jakarta.
  • Noenoeng Rahajoe Department of Child Health, Medical School, University of Indonesia, Jakarta.
  • I. Boediman Department of Child Health, Medical School, University of Indonesia, Jakarta.
  • Mardjanis Said Department of Child Health, Medical School, University of Indonesia, Jakarta.
  • S. Lazuardi Department of Neurology, Medical School, University of Indonesia, Jakarta.
Keywords: tuberculous meningitis, isoniazid, rifampicin, streptomycin

Abstract

Twenty-two cases of tuberculous meningitis have been treated with isoniazid, streptomycin and rifampicin and 19 cases with isoniazid, P.A.S. and streptomycin. Both groups received corticosteroid at the beginning of the treatment. The 2 groups were compared on the clinical and neurological improvement, duration of necessary hospitalization, the presence of sequelae, and the death rate. Also the tolerability of both regimens was compared.

References

CAMPOS, L.D., FONTOURA, E. and DUARTE, G. : The present treatment schedule of tuberculous meningitis in the Pavilhae Infantil Roberto Rangel Lima, in conjunction with Sanaiorial Rafael de Paula Souza. XVth National Congress on Tuberculosis, Curitiba-Parana, 1970.

DIEU, J.Cl. : Role de l’Isoniazide dans l’hepattotoxite de l’association INH = Rifampicinc dans la tuberculose de l’enfant. J. Med. Lyon 53 - 1323 (1972).

KUTT, H., WINTERS, W. and McDOWEL.L, F H. : Depression of Parahydroxylation of Diphenylhydantion by Antituberculosis Therapy. Neurology (Minneap.) 16:594 (1966).

RAHAJOE, N.N., SUTOTO, RAHAJOE, N., BOEDIMAN, I. and SUTEJO : Rifampicin in combination with isoniazid in the treatment cf childhood tuberculosis. Paediatr. Indones. 16 : 544 (1976).

SASTROASMORO, S., RAHAJOE, N., RAHAJOE, N.N., BOEDIMAN, I. and SAID, M. : Isoniazid-rifampicin associated hepatitis. IVth Nat. Congr. Indones. Pediatr., Yogyakarta, 1978.

THE MEDICAL RESEARCH COUNCIL OF GREAT BRITAIN (as cited by Gilroy. J. and Meyer, J.S. in Medical Neurology. pp. 364 - 367 (Macmillian, Toronto 1969).

VISUDHIPHAN P. and CHIEMCHANYA, S. : Evaluation of rifampicin in the treatment of tuberculous meningitis in children. J. Pediatr. 87 : 983 (1975).
Published
2017-06-16
How to Cite
1.
Rahajoe N, Rahajoe N, Boediman I, Said M, Lazuardi S. The Treatment of Tuberculous Meningitis in Children with A Combination of Isoniazid, Rifampicin and Streptomycin (A preliminary report). PI [Internet]. 16Jun.2017 [cited 19Apr.2024];19(11-12):285-4. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1543
Received 2017-06-15
Accepted 2017-06-15
Published 2017-06-16