Glucose-6-Phosphate Dehydrogenase Deficiency in the Dr. Cipto Mangunkusumo General Hospital
Keywords:
glucose-6-phosphate-dehydrogenase (G-6-P-D) deficiency,
Abstract
The incidence of G-6-P-D deficiency in Indonesia is not yet known. So far only Inyo Luan Eng (1964) reported the incidence in some parts of Indonesia. Other data are only from case reports. This study which consisted of 3200 babies -- born in the Dr. Cipto Mangunkusumo General Hospital from September 1975 through October 1976 proved that the incidence is high enough that is 2.66% (85 out of 3200). The hemoglobin content of G-6-P-D deficient babies showed an average of 14.4 g%. This gives us an idea that there is slight anemia in these babies. The incidence of jaundice was 35 out of 85 (41%). Factors inducing jaundice were infection, hypoxia and sub-aponeurotic bleeding. Of 60 which could be examined quantitatively only 2 showed a G-6-P-D activity level of more than 120 mu/10^9 RBC, so that the screening method could be used for early detection of G-6-P-D deficiency.References
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YUE, P.C.P. and STRICKLAN, M. : Glucose-6-Phosphate-Dehydrogenese deficiency and Neonatal Jaundice in Chinese Male infants in Hongkong. Lancet i : 350 (1965).
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BROWN, W.R. and WONG HOCK BOON : Hyperbilirubinemia and kernicterus in G-6-P-D deficient infants in Singapore, Pediatr. 41 : 1055 (1968).
CAPPS, F.P.A.; GILLES, H.M.; JOLLY, H. and WORLLEDGE, S.M. : G-6-P-D deficiency and neonatal jaundice in Nigeria their relation to the use of prophyla- tic vit. K. Lancet. 24 : 379 (1963).
CARSON (1956), cited by DOXIAD1S et al. (1961).
DOX1ADIS, S.A.; VALAES, T.; KARAKLIS, A. and STAVRAKALIS, D. : Risk of severe jaundice in G-6-P-D deficiency of he newborn. Lancet, ii : 1210 (1964).
DOXIADIS, S.A.; FESSAS, Ph. and VALAES, T. : Glucose-6-Phosphate-Dehydrogenese deficiency, A new aetiological factor of severe Neonatal Jaundice. Lancet i : 297 (1961).
FESSAS, P.; DOXIADIS, S.A. and VALAES, T. : Neonatal Jaundice in G-6-P-D deficient infants. Br. med. J., 24 : 1358 (1962).
FONG, T : Prevalence of Erythrocyte G-6-P-D deficiency in Sabah. Mod. med. Asia, 13 : 14 (1977).
INYO LUAN ENG : Nature, 204 : 88 (1964).
JAYADIMAN GATOT : Personal Communication (1974).
MONINTJA, H.E.; WIRASTARI, B.; KADRI, N.; AMINULLAH, A. and MUSLICHAN, S. : Problems of Neonatal Jaundice in Indonesia. 1. The incidence and Etiological Factors in the Dr. Cipto Mangunkusumo Hospital, Jakarta (to be published) (1978).
NOTOPURO, H. and DONOSEPUTRO, M. : Glucose-6-Phosphate-Dehydrogenase (G-6-P-D) pada Eritrosit. Maj. Kedok. Surabaya 1 : 18 (1970).
O’FLYNN, M.E. and HISTIA, D.Y.: Serum bilirubin levels and Glucose-6-Phosphate-Dehydrogenase deficiency in newborn American Negroes, J. Pediatr. 63 : 160 (I960).
PANICH, V. and NA — NAKORN, S : Acute hemolysis in G-6-P-D union (Thai). J. med. Assoc. Thailand, 56 : 241 (1973).
PANIZON, F. : Erythrocyte enzyme deficiency in unexplained kern icterus. Lancet. i : 1093 (1960).
SAMSONE, G.; PERRONI, L. and YOSHIDA, A. : Glucose-6-Phosphate-Dehydrogenase variants from Italian Subjects Associated with severe Neonatal Jaundice. Br. Hematol. 31 : 159 (1975).
SISWADI, L; NOTOPURO, H. and UNTARIO, S. : G-6-P-D deficiency. Paediatr. Indones. 12 : 182 (1972).
SMITH, G.S. and VELLA, F. : Erythrocyte enzyme deficiency in unexplained kern icterus. Lancet i : 1133 (1960).
SZEINBERG, A.; OLIVER, M.; SCHIMIDT, R. and SHEBA, CH.: Glucose-6-Phosphate-Dehydrogenase deficiency and haemolitic disease at the newborn in Israel. Arch. Dis. Childh. 38 : 23 (1963).
TARLOV, A.R.; BREWER, G.J.; CARSON, P.E.; and ALVING, A.S. (1962); Cited by Young et al. (1974).
TUCHINDA (1968) cited by PANICH and N.A. NAKORN (1973).
VELLA, F. Med. J. Malaya 13 : 298. (1959).
WEATHERALL, D.J. : Enzyme deficiency in haemolityc disease of the newborn. Lancet ii : 835 (1960).
WHO Scientific Group : Standardization of procedures for the study of Glucose-6-Phosphate-Dehydrogenese. WHO Tech. Rep. Ser. 366, Geneva, 1967.
WONG HOCK BOON : — Hyperbilirubinemia and kern icterus in Singapore. J. Singapore Pediatr. Soc. 6 : 1 (1964). — Personal communication (1978).
YUE, P.C.P. and STRICKLAN, M. : Glucose-6-Phosphate-Dehydrogenese deficiency and Neonatal Jaundice in Chinese Male infants in Hongkong. Lancet i : 350 (1965).
YOSHIDA, A. and LIN, M.; Regulation of Glucose-6-Phosphate-Dehydrogenese activity in red blood cells from hemolysis. Blood 41 : 877 (1973).
YOUNG, G.P.; SMITH, M.B. and WOODFILED, D.G. : G-6-P-D deficiency in Papua New Guinea, using simple methylene blue reduction test. Med. J. Aust. 1 : 876 (1974).
ZINKHAM, W.H. : Periperal blood and bilirubin values in normal fullterm primaquine-sensitive Negro infants : Effect of vitamin K. Pediatr. 31 : 983
(1963).
ZINKHAM and CHILD (1957) cited by Capps et. al (1963).
Published
2017-06-16
How to Cite
1.
Suradi R, Monitja H, Munthe B, Suparno S. Glucose-6-Phosphate Dehydrogenase Deficiency in the Dr. Cipto Mangunkusumo General Hospital. PI [Internet]. 16Jun.2017 [cited 24Apr.2024];19(1-2):30-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1525
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Received 2017-06-14
Accepted 2017-06-14
Published 2017-06-16
Accepted 2017-06-14
Published 2017-06-16
