Some Problems of Thalassemia in Jakarta
Keywords:
thalassemia, Hb E, Hb H, Hb S
Abstract
Within 10 years (1964 - 1974) two hundred and twenty one thalassemic children were observed in the Department of Child Health, Medical School, University of Indonesia in Jakarta. They consisted of 119 cases of thalassemia major, 95 thalassemia Hb E disease, 6 Hb H disease and 1 thalassemia Hb S disease. The main treatment of thalassemia major is still blood transfusion. Splenectomy was performed on 29 children with thalassemia major and 26 cases with thalassemia Hb E disease. Splenectomy performed on cases before hypersplenism appeared, showed better results then those late cases who have already symptoms of hypersplenism. Beside the medical points of view thalassemia has also many social aspects to be considered, those of the child itself, the parents and the society or community.References
BETKE, K., MARTI, H.R. and SCHLICHT, I. : Estimation of small percentage of foetal hemoglobin. Nature. Lond. 184 : 1877 (1959).
DACIE, J.V. and LEWIS, S.M. : Practical hematology, 3rd. ed. (Churchil, London 1963).
HORAN, M.B. and COLEBATCH, J.H.: Relation between splenectomy and subsequent infection. Arh. Dis. Childh. 37 : 398 (1962).
KUNKEL, H:G., CEPELINI, R., MULLER-EBERHARD, U. and WOLF, J. : Observations on the minor basic hemoglobin component in blood of normal individuals and patients with thalassemia. J. clin. Invest. 36 : 1615 (1957).
LICHTMAN, H:C;; WATSON, R,J.; FELDMAN, F.; GINSBERG, V. and ROBINSON, J. : Studies on thalassemia: I. An extra corpuscular defect in thalassemia major. II. The effect of splenectomy in thalassemia major with an associated acquired hemolytic anemia. J. clin. Invest. 32 : 1229 (1953).
MOTULSKY, A.G.; CASSERD, F.; E.R; BROUN, G.O., Jr. and FINCH, C.H. : Anemia and spleen. New Engl. J. Med. 259 : 1164 (1958).
ORSINI, A. : Die thalassamien. Nouv. Presse med. 2 : 2089 (1973). Cited from: Pediatrics Zentralblatt fur die gesamte Kinderheilkunde 115 : 260 (1975).
SMITH, C.H.; ERLADSON, M:E.; STERN, G. and SCHULMAN, I. : The role of splenectomy in the management of thalassemia. Blood 15 : 197 (1960).
TAFT, L.E. and MILLER, A.G. : Thalassemia l. Pathogenesis and diagnosis. Austr. paediatr. J. 4 : 156 (1968).
WOLMAN, I.J. : Transfusion therapy as related to long-range haemoglobin levels. A progress report. Ann. N.Y. Acad. in Cooley's anemia: Growth and health Sci. 119 : 736 (1964).
WOLMAN, I.J. and ORTOLANI, M. : Some clinical features of Cooley's anemia patients as related to transfusion schedules. Ann. N.Y. Acad. Sci. 165 : 407 (1969).
DACIE, J.V. and LEWIS, S.M. : Practical hematology, 3rd. ed. (Churchil, London 1963).
HORAN, M.B. and COLEBATCH, J.H.: Relation between splenectomy and subsequent infection. Arh. Dis. Childh. 37 : 398 (1962).
KUNKEL, H:G., CEPELINI, R., MULLER-EBERHARD, U. and WOLF, J. : Observations on the minor basic hemoglobin component in blood of normal individuals and patients with thalassemia. J. clin. Invest. 36 : 1615 (1957).
LICHTMAN, H:C;; WATSON, R,J.; FELDMAN, F.; GINSBERG, V. and ROBINSON, J. : Studies on thalassemia: I. An extra corpuscular defect in thalassemia major. II. The effect of splenectomy in thalassemia major with an associated acquired hemolytic anemia. J. clin. Invest. 32 : 1229 (1953).
MOTULSKY, A.G.; CASSERD, F.; E.R; BROUN, G.O., Jr. and FINCH, C.H. : Anemia and spleen. New Engl. J. Med. 259 : 1164 (1958).
ORSINI, A. : Die thalassamien. Nouv. Presse med. 2 : 2089 (1973). Cited from: Pediatrics Zentralblatt fur die gesamte Kinderheilkunde 115 : 260 (1975).
SMITH, C.H.; ERLADSON, M:E.; STERN, G. and SCHULMAN, I. : The role of splenectomy in the management of thalassemia. Blood 15 : 197 (1960).
TAFT, L.E. and MILLER, A.G. : Thalassemia l. Pathogenesis and diagnosis. Austr. paediatr. J. 4 : 156 (1968).
WOLMAN, I.J. : Transfusion therapy as related to long-range haemoglobin levels. A progress report. Ann. N.Y. Acad. in Cooley's anemia: Growth and health Sci. 119 : 736 (1964).
WOLMAN, I.J. and ORTOLANI, M. : Some clinical features of Cooley's anemia patients as related to transfusion schedules. Ann. N.Y. Acad. Sci. 165 : 407 (1969).
Published
2017-06-13
How to Cite
1.
Wahidiyat I, Markum A, Abdulsalam M, Muslichan S. Some Problems of Thalassemia in Jakarta. PI [Internet]. 13Jun.2017 [cited 5Dec.2024];18(3-4):100-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1467
Section
Articles
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Received 2017-06-02
Accepted 2017-06-02
Published 2017-06-13
Accepted 2017-06-02
Published 2017-06-13
