Treatment of Cholera El Tor with Bactrim
Keywords:
Cholera El Tor, Bactrim.
Abstract
Between November 1971 and May 1974, there were 41 children, comprising 26 boys and 15 girls, suffering from cholera El Tor gastroenteritis treated with parenteral Bactrim during the first 24 hours followed by Bactrim orally for 4 consecutive days. Rectal swabs on admission showed positive V. cholera biotype El- Tor cultures in all cases; 9 children had additional pathogenic E. coli in the stools. Besides Bactrim, treatment consisted of intravenous administration of lactated Ringer’s solution, dextrose 5% or saline. All the patients showed quick improvement of the clinical condition. Good result was found in 34 children (82.9%), fair in 6 (14.6%), and failure in 1 case (2.4%). All the children in this study survived. No drug intolerance or side effect was observed.References
BONANG, G., KANDOU, H., BARAMULI, C. and LINTONG, M.: Penentuan kepekaan vibrio El Tor, vibrio Cholera dan vibrio NAG terhadap trimethoprim — sulphamethoxazole dengan cara penipisan lempeng agar dst. oxoid dan cara cakram. Maj. Kedok. Indones. 11 : 489 (1970).
CARPENTER, C.C.J. and HIRSCHHORN: Paediatric cholera: current concept of therapy. J. Pediatr. 80 : 874 (1972).
FELISARDO, F.O., ATIENZE, R., LOPEZ, W.L. and VILLEGAS, J.K. : Preliminary clinical experiences on the use of antimicrobials in cholera El Tor. National symposium on the clinical efficacy of a new antimicrobial: Trimethoprim-sulphamethoxazole. Manila, Philippines, 1969.
FELSENFELD, O. : Review of recent trend in cholera research and control with annex on the isolation and identification of cholera vibrios. Bull. WHO 34 : 161 (1966).
GHARAGOZLOO, R.A., NAFICY, K., MUIN. M., NASSIRZADAL, M.H. and YALDA, R. : Comparative trial of tetracycline, chloramphenicol and trimethoprim-sulphamethoxazole in eradication of vibrio cholerae El Tor. Br. med. J. 4 : 281 (1970).
GUTMAN, R.A., DRUTZ, D.J., WHALAE, G.E. and WATTEN, R.H. : Double-blind fluid therapy evaluation in paediatric cholera. Pediatr. 44 : 922 (1969).
ISWANDARI, J., ERAWAN, H., KOMALARINI, S. and NJOTOSISWOJO, S.: Cholera El Tor enteritis in Jakarta. Paediatr. Indones. 13 : 55 (1973).
ISWANDARI, J., KOMALARINI, S. and KHO, L.K.: Parenteral Bactrim in the management of gastroenteritis in particular of cholera El Tor in childhood. Asian J. Med, 10 : 125 (1974).
KOMALARINI, S. and JOSEPH, S.W.: Gastroenteritis due to Vibrio parahaemolyticus. Modern Med. 11 : 9 (1975).
LINDENBAUM, J., GREENOUGH, B. W. and ISLAM, M.R.: Antibiotic therapy of cholera. Bull. WHO 34 : 871 (1967).
NJOTOSISWOJO, S., KOMALARINI, S., ISWANDARI, J. and KHO, L.K.: Sensitivity test of enterobacteriaceae in diarrhoeal diseases in Jakarta. South East Asian J. trop. med. (Publ. Hlth.) 3 : 326 (1972).
TANZIL, H.O.K., WARSA, R., ERFANI, ASSANI, S. and SURACHMAN: Multidisks method for determining the sensitivity of microorganisms isolated from pathological specimens to Bactrim comipared with other antibiotics. Indones. J. (Publ. Hith.) 3 : 54 (1970).
CARPENTER, C.C.J. and HIRSCHHORN: Paediatric cholera: current concept of therapy. J. Pediatr. 80 : 874 (1972).
FELISARDO, F.O., ATIENZE, R., LOPEZ, W.L. and VILLEGAS, J.K. : Preliminary clinical experiences on the use of antimicrobials in cholera El Tor. National symposium on the clinical efficacy of a new antimicrobial: Trimethoprim-sulphamethoxazole. Manila, Philippines, 1969.
FELSENFELD, O. : Review of recent trend in cholera research and control with annex on the isolation and identification of cholera vibrios. Bull. WHO 34 : 161 (1966).
GHARAGOZLOO, R.A., NAFICY, K., MUIN. M., NASSIRZADAL, M.H. and YALDA, R. : Comparative trial of tetracycline, chloramphenicol and trimethoprim-sulphamethoxazole in eradication of vibrio cholerae El Tor. Br. med. J. 4 : 281 (1970).
GUTMAN, R.A., DRUTZ, D.J., WHALAE, G.E. and WATTEN, R.H. : Double-blind fluid therapy evaluation in paediatric cholera. Pediatr. 44 : 922 (1969).
ISWANDARI, J., ERAWAN, H., KOMALARINI, S. and NJOTOSISWOJO, S.: Cholera El Tor enteritis in Jakarta. Paediatr. Indones. 13 : 55 (1973).
ISWANDARI, J., KOMALARINI, S. and KHO, L.K.: Parenteral Bactrim in the management of gastroenteritis in particular of cholera El Tor in childhood. Asian J. Med, 10 : 125 (1974).
KOMALARINI, S. and JOSEPH, S.W.: Gastroenteritis due to Vibrio parahaemolyticus. Modern Med. 11 : 9 (1975).
LINDENBAUM, J., GREENOUGH, B. W. and ISLAM, M.R.: Antibiotic therapy of cholera. Bull. WHO 34 : 871 (1967).
NJOTOSISWOJO, S., KOMALARINI, S., ISWANDARI, J. and KHO, L.K.: Sensitivity test of enterobacteriaceae in diarrhoeal diseases in Jakarta. South East Asian J. trop. med. (Publ. Hlth.) 3 : 326 (1972).
TANZIL, H.O.K., WARSA, R., ERFANI, ASSANI, S. and SURACHMAN: Multidisks method for determining the sensitivity of microorganisms isolated from pathological specimens to Bactrim comipared with other antibiotics. Indones. J. (Publ. Hith.) 3 : 54 (1970).
Published
2017-05-29
How to Cite
1.
Komalarini S, Iswandari J. Treatment of Cholera El Tor with Bactrim. PI [Internet]. 29May2017 [cited 15Jan.2025];15(7-8):207-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1420
Section
Articles
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Received 2017-05-26
Accepted 2017-05-26
Published 2017-05-29
Accepted 2017-05-26
Published 2017-05-29
