Complete giant liver cell transformation with an unusual good clinical and histological course

  • Mohamad Adat Department of Child Health and Institute of Pathology, University of Indonesia Medical School, Jakarta
  • Sadikin Darmawan Department of Child Health and Institute of Pathology, University of Indonesia Medical School, Jakarta
  • A. H. Markum Department of Child Health and Institute of Pathology, University of Indonesia Medical School, Jakarta
DOI: https://doi.org/10.14238/pi13.3.1973.103-12
Keywords: giant liver cell transformation, hepatitis, biliary atresia, histopathologic feature

Abstract

A form of hepatitis occurring in the neonatal period and clinically simulating biliary atresia was first described by Craig and Landing in
1952. The characteristic histopathologic feature of the disease at biopsy and autopsy was the presence of multinucleated giant liver cells replacing most of the parenchyma. The general architecture of the liver lobule however was preserved, the portal triads and central veins were in their usual places. Because of these characteristic giant cells, the disease is
called giant cell hepatitis, giant liver cell transformation, sometimes also neonatal hepatitis, because it was thought to occur only in neonates.

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Published
1973-03-30
How to Cite
1.
Adat M, Darmawan S, Markum A. Complete giant liver cell transformation with an unusual good clinical and histological course. PI [Internet]. 30Mar.1973 [cited 24Apr.2024];13(3):103-2. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1329
Issue
Vol 13 No 3 (1973): March 1973
Section
Case Report

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Received 2017-03-30
Published 1973-03-30