Body mass index, atopy, and allergic diseases

Main Article Content

Afnita Lestary
Lily Irsa
Tiangsa Sembiring
Rita Evalina
Meiviliani Sinaga


Background Prevalence of atopy, allergic diseases, and obesity are increasing. Atopy is an individu and/or familial tendency to sensitization in response to ordinary exposure to allergens. Studies on association of BM I with atopy and allergic diseases in children were limited, with inconclusive results.

Objective To assess associations of BM I with atopy and allergic diseases in chidren.

Methods A cross-sectional was conducted in school children aged 6-12 years in Lhokseumawe City, Aceh, June 2012. Children were assessed for BMI, skin prick test, and International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Statistical analyses included Chi-square, Fisher exact, and logistic regression.

Results The subjects consisted of 137 (85.6%) normoweight, 12 (7.5%) overweight, and 11 (6.9%) obesity. Skin prick test results were positive in 44 (27.5%) and negative in 116 (72.5%) subjects. Allergic manifestations were allergic rhinitis (AR) 17 (10.6%), bronchial asthma 6 (3.8%), and atopic dermatitis (AD) 3 (1.9%). There was significant association of obesity with atopy, compared with normoweight (OR=3.78; 95%CI 1.08 to 13.19; P=0.037), but no significant association found when family history of atopy also assesed. There was significant association of obesity with bronchial asthma (OR=9.92; 95%CI 1.46 to 67.18; P=0.004) and AR (OR=6.49; 95%CI 1.64 to 25.66; P=0.015), compared with normoweight children. Significant association of overweight with atopy and allergic disease were not found.

Conclusion Obese children are more likely to have atopy, bronchial asthma, and allergic rhinitis, but overweight and normoweight children are not.

Article Details

How to Cite
Lestary A, Irsa L, Sembiring T, Evalina R, Sinaga M. Body mass index, atopy, and allergic diseases. PI [Internet]. 19Oct.2016 [cited 6Apr.2020];56(4):221-. Available from:
Received 2016-08-04
Accepted 2016-09-05
Published 2016-10-19


1. Johansson SG, Bieber T, Dahl R, Friedmann PS, Lanier BQ, Lockey RF, et al. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization. J Allergy Clin Immunol. 2004;113:832-6.
2. Liu AH, Martinez FD, Taussig LM. Natural history of allergic diseases and asthma. In: Leung DYM, editor. Pediatric allergy: principles and practice. 2nd ed. New York: Elsevier; 2010. p. 9-18.
3. Asher MI, Montefort S, Björkstén B, Lai CK, Strachan DP, Weiland SK, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet. 2006;368:733–43.
4. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA. 2006;295:1549-55.
5. Visness CM, London SJ, Daniels JL, Kaufman JS, Yeatts KB, Siega-Riz AM, et al. Association of obesity with IgE levels and allergy symptoms in children and adolescents: results from the National Health and Nutrition Examination Survey 2005-2006. J Allergy Clin Immunol. 2009;123:1163-9.
6. Leung TF, Kong AP, Chan IH, Choi KC, Ho CS, Chan MH, et al. Association between obesity and atopy in Chinese schoolchildren. Int Arch Allergy Immunol. 2009;149:133-40.
7. Magnusson JÖ, Kull I, Mai XM, Wickman M, Bergstrom A. Early childhood overweight and asthma and allergic sensitization at 8 years of age. Pediatrics. 2012;129:70-6.
8. Mai XM, Nilsson L, Axelson O, Braback L, Sandin A, Kjellman NI, et al. High body mass index, asthma and allergy in Swedish schoolchildren participating in the International Study of Asthma and Allergies in Childhood: Phase II. Acta Paediatr. 2003;92:1144-8.
9. Vlaski E, Stavric K, Isjanovska R, Seckova L, Kimovska M. Overweight hypothesis in asthma and eczema in young adolescents. Allergol Immunopathol. 2006;34:199-205.
10. Eldin LB, Algamal HA, El-Dory GF, Rashad M, El-Arab SE, Al-ella NAA, et al. Relation between obesity, lipid profile, leptin and atopic disorders in children. Egypt J Pediatr Allergy Immunol. 2008;6:27-34.
11. Irene AL, Klipstein-Grobusch K, Amoah AS, Obeng BB, Wilson MD, Yazdanbakhsh M, et al. High body mass index is not associated with atopy in schoolchildren living in rural and urban areas of Ghana. BMC Public Health. 2011;11:469-78.
12. Apandi PR, Setiabudiawan B, Sukadi A. Correlation between obesity with atopy and family history of atopy in children. Paediatr Indones. 2011;51;227-33.
13. Kumar R, Singh BP, Srivastava P, Sridhara S, Arora N, Gaur SN. Relevance of serum IgE estimation in allergic bronchial asthma with special reference to food allergy. Asian Pac J Allergy Immunol. 2006;24:191-9.
14. Rona RJ, Keil T, Summers C, Gislason D, Zuidmeer L, Sodergren E, et al. The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol. 2007;120:638-46.
15. Sidabutar S, Munasir Z, Pulungan AB, Hendarto A, Tumbelaka AR, Firman K. Sensitisasi alergen makanan dan hirupan pada anak dermatitis atopik setelah mencapai usia 2 tahun. Sari Pediatri. 2011;13:147-51.
16. Singh AB, Shahi S. Aeroallergens in clinical practice of allergy in India- ARIA Asia Pacific Workshop report. Asian Pac J Allergy Immunol. 2008;26:245-56.
17. Stipić-Marković A, Pevec B, Pevec MR, Custović A. Prevalence of symptoms of asthma, allergic rhinitis, conjunctivitis and atopic eczema: ISAAC (International Study of Asthma and Allergies in Childhood) in a population of schoolchildren in Zagreb. Acta Med Croatica. 2003;57:281-5.
18. Silva MJ, Ribeiro MC, Carvalho F, Oliveira GJM. Atopic disease and body mass index. Allergol Immunopathol. 2007;35:130-5.
19. Gysel VD, Govaere E, Verhamme K, Doli E, Baets DF. Body mass index in Belgian schoolchildren and its relationship with sensitization and allergic symptoms. Pediatr Allergy Immunol. 2009;20:246-53.
20. Borrego TJ, Teran MAB, Mendoza MC. Prevalence and associated factors of allergic rhinitis and atopic dermatitis in children. Allergol Immunopathol. 2008;36:90-100.
21. Silverberg JI, Kleiman E, Lev-Tov H, Silverberg NB, Durkin HG, Joks R, et al. Association between obesity and atopic dermatitis in childhood: a case-control study. J Allergy Clin Immunol. 2011;127:1180-6.
22. Speiser PW, Rudolf MC, Anhalt H, Hubner CC, Chiarelli F, Eliakim A, et al. Childhood obesity. J Clin Endocrinol Metab. 2005;90:1871-87.
23. Lago F, Dieguez C, Reino GJ, Gualillo O. The emerging role of adipokines as mediators of inflammation and immune responses. Cytokine Growth Factor Rev. 2007;18:313–25.
24. Asher MI, Keil U, Anderson HR, Beasley R, Crane J, Martinez F, et al. International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J. 1995;8:483–91.