Some clinical and epidemiological observations on virologically confirmed dengue hemorrhagic fever

  • T. K. Samsi Department of Pediatrics, Sumber Waras Hospital/Tarumanegara University, Jakarta
  • H. Wulur Department of Pediatrics, Sumber Waras Hospital/Tarumanegara University, Jakarta
  • D. Sugianto Department of Pediatrics, Sumber Waras Hospital/Tarumanegara University, Jakarta
  • C. R. Bartz US Naval Medical Research Unit No. 2 Detachment, Jakarta
  • R. Tan US Naval Medical Research Unit No. 2 Detachment, Jakarta
  • A. Sie US Naval Medical Research Unit No. 2 Detachment, Jakarta
DOI: https://doi.org/10.14238/pi30.11-12.1990.293-303
Keywords: dengue hemorrhagic fever, virologically confirmed, thrombocytopenia, shock

Abstract

This study is a part of a one year prospective study on dengue hemorrhagic fever (DHF) carried out in the Department of Pediatrics, Sumber Waras Hospital in West Jakarta. Viral isolation and serologic analysis for DHF were done by Namru-2 in Jakarta.

The subjects were 151 virologically confirmed DHF Patients admitted to the Department of Pediatrics during the period of September 1987 - June 1988, consisting of 82 boys and 69 girls of 6 months - 15 years old.

The predominant age group was 5 to 9 years, representing 49. 7% subjects. Dengue virus was isolated from sera during the first 8 days of illness and in 139 (42.1%) during the first. 5 days of illness. Dengue virus type 1, 2, 3 and 4 were isolated from 16.6%, 13.2%, 69.5% and 0 . 7% subjects, respectively.

The clinical manifestations revealed no striking differences between dengue 3 and others except for thrombocytopenia and shock. High fever, hemoconcentration and thrombocytopenia on admission was observed in 30.5%, 8,6% and 8.6% of subjects, respectively.

Dengue shock syndrome (DSS) were observed in 23 (15.2%) with 3 (2%) fatal cases. Dengue virus serotype 3 was observed in 20 out of 23 DSS cases (86,9%) and all fatal cases were associated with dengue type 2. This study revealed that dengue 3 is the predominant virus circulating during recent epidemics and is associated with more severe clinical manifestation and with a higher incidence rate of living area.

References

1. GUBLER, D.1.; SUHARYONO, W.; SUMARMO; WULUR, H.; JABlA, E.; and SULlANTI SAROSO, 1.: Virological surveillance for Dengue fever in Indonesia with the mosquito inoculation technique. Bull. WId, Hlth. Org. 57: 931, 1976 (a).
2. GUBLER, D.J.; SUMARMO; WULUR, H.; and SULIANTO SAROSO. J.: Magnitude and duration of Viremia in Dengue Hemorrhagic Fever Patients in Jakarta, Indonesia. Abstract presented in Conference on UHF, Bangkok 13-20 October 1976 (b).
3. GUBLER, D.l.; SUHARYONO, W.; LUBIS, I.; ERAM, S.; and SULIANTI SAROSO, J.: Epidemic Dengue Hemorrhagic Fever in rural Indonesia. (Virological and Epidemiological studies) Am. 1. trop. Med. Hyg. 28: 701-710. 1979.
4. SIDHARTA, H.; WULUR, H.; MELANI, W.S.; JANI SIMKOPUTRA; KARTlKA, J.; and TATANG, K.S.: Ka.'ius Demam Berdarah Dengue selama 20 tahun di R.S. Sumber Waras. Simposium Dwidasawarsa Ilmu Kesehatan Anak R.S. Sumber Waras. Jakarta, December 11-12, 1987.
5. MUSLIM, A.N.; SRI REZEKI HARUN and SUMARMO: Dengue Hemorrhagic Fever and Japanese B. Encephalitis in Indonesia. Southeast Asian J. trop. Med. Pub. HUh 19: 3, 1988.
6. NIMANITYA, S.; HALSTED, S.B.; COHEN, S.N.; and MARGIOTTA, M.R.: Dengue and Chikungunya Virus Infection in man in Thailand (Observation on hospitalized patients with Hemorrhagic Fever). Am. J. trop. Med. Hyg. 18: 904, 1969.
7. SUMARMO; WULUR, H.; lAHJA, E.; GUBLER, D.l.; SUHARYONO, W.; and SORENSEN, K.: Clinical observation on virologically confmned fatal dengue infection in Jakarta. Indonesia. Bul. Wid. Hlth. Org. 61: 693, 1983.
8. SUMARMO; SUHARYONO, W.; and GUBLER, D.J.: Clinical observation on hospitalized patients with virologically confirmed DHF in Jakarta. Indonesia, 1975-1983. Paediatr. Indones. 26: 137, 1986.
9. SUROSO, T.; and BANG, Y.H.: Control and proceeding of Dengue Hemorrhagic Fever in Indonesia strategy and thrust. Dengue Newsletter II: 17, 1985.
10. SUROSO: Peranan dokter dalam pemberantasan Demam Berdarah. Simposium Dwidasawarsa IImu Kesehatan Anak R.S. Sumber Waras, Jakarta, 11-12 Desember, 1987.
11. TATANG, K.S.; SUSANTO, I.: Pengobatan dini dan penatalaksanaan Demam Berdarah Dengue. Simposium Dwidarsawarsa Ilmu Kesehatan Anak R.S. Sumber Waras, Jakarta, 11-12 Desember, 1987.
12. WHO: Dengue Hemorrhagic Fever: diagnose, treatment and Control, Geneva, 1986.
Published
1990-12-31
How to Cite
1.
Samsi T, Wulur H, Sugianto D, Bartz C, Tan R, Sie A. Some clinical and epidemiological observations on virologically confirmed dengue hemorrhagic fever. PI [Internet]. 31Dec.1990 [cited 6Feb.2025];30(11-12):293-0. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1293
Issue
Vol 30 No 11-12 (1990): November - December 1990
Section
Infection & Tropical Pediatrics

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Received 2017-02-23
Accepted 2017-02-23
Published 1990-12-31