Some clinical and epidemiological observations on virologically confirmed dengue hemorrhagic fever

  • T. K. Samsi Department of Pediatrics, Sumber Waras Hospital/Tarumanegara University, Jakarta
  • H. Wulur Department of Pediatrics, Sumber Waras Hospital/Tarumanegara University, Jakarta
  • D. Sugianto Department of Pediatrics, Sumber Waras Hospital/Tarumanegara University, Jakarta
  • C. R. Bartz US Naval Medical Research Unit No. 2 Detachment, Jakarta
  • R. Tan US Naval Medical Research Unit No. 2 Detachment, Jakarta
  • A. Sie US Naval Medical Research Unit No. 2 Detachment, Jakarta
DOI: https://doi.org/10.14238/pi30.11-12.1990.293-303
Keywords: dengue hemorrhagic fever, virologically confirmed, thrombocytopenia, shock

Abstract

This study is a part of a one year prospective study on dengue hemorrhagic fever (DHF) carried out in the Department of Pediatrics, Sumber Waras Hospital in West Jakarta. Viral isolation and serologic analysis for DHF were done by Namru-2 in Jakarta.

The subjects were 151 virologically confirmed DHF Patients admitted to the Department of Pediatrics during the period of September 1987 - June 1988, consisting of 82 boys and 69 girls of 6 months - 15 years old.

The predominant age group was 5 to 9 years, representing 49. 7% subjects. Dengue virus was isolated from sera during the first 8 days of illness and in 139 (42.1%) during the first. 5 days of illness. Dengue virus type 1, 2, 3 and 4 were isolated from 16.6%, 13.2%, 69.5% and 0 . 7% subjects, respectively.

The clinical manifestations revealed no striking differences between dengue 3 and others except for thrombocytopenia and shock. High fever, hemoconcentration and thrombocytopenia on admission was observed in 30.5%, 8,6% and 8.6% of subjects, respectively.

Dengue shock syndrome (DSS) were observed in 23 (15.2%) with 3 (2%) fatal cases. Dengue virus serotype 3 was observed in 20 out of 23 DSS cases (86,9%) and all fatal cases were associated with dengue type 2. This study revealed that dengue 3 is the predominant virus circulating during recent epidemics and is associated with more severe clinical manifestation and with a higher incidence rate of living area.

References

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2. GUBLER, D.J.; SUMARMO; WULUR, H.; and SULIANTO SAROSO. J.: Magnitude and duration of Viremia in Dengue Hemorrhagic Fever Patients in Jakarta, Indonesia. Abstract presented in Conference on UHF, Bangkok 13-20 October 1976 (b).
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Published
1990-12-31
How to Cite
1.
Samsi T, Wulur H, Sugianto D, Bartz C, Tan R, Sie A. Some clinical and epidemiological observations on virologically confirmed dengue hemorrhagic fever. PI [Internet]. 31Dec.1990 [cited 20Apr.2024];30(11-12):293-0. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1293
Issue
Vol 30 No 11-12 (1990): November - December 1990
Section
Infection & Tropical Pediatrics

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Received 2017-02-23
Accepted 2017-02-23
Published 1990-12-31