Genetic inheritance pattern in prurigo Hebra

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Siti Aisah Boediardja
Wahyuning Ramelan
Santoso Cornain


A study was conducted to analyze the multifactorial genetic inheritance pattern in prurigo Hebra (PH). Fifty
probands (PH patients) consisting of 11 males and 39 females, with age ranged from 5-30 years were included in this study.
A three-generation family tree was obtained from each subject, from which a total of 79 families were eligible for analysis. For
each family the possible mode of inheritance, namely autosomal dominant (AD) or autosomal recessive (AR), was predicted.
The families were then grouped according to the mode of inheritance. Analysis was conducted using Chi-square test,
comparing the observed occurrence of PH and the expected value for each mode. To rule out mutation, the second method
was applied, which only families with more than one affected child were analyzed, was used. The genetic inheritance
pattern was not consistently compatible either with AR or AD. This finding, and other supporting facts, such as female
preponderace, the role of HLA and the lower morbidity rate compared to the expected rate in AR or AD mode, indicated that
the genetic inheritance of PH follows a multi-factorial pattern.

Article Details

How to Cite
Boediardja S, Ramelan W, Cornain S. Genetic inheritance pattern in prurigo Hebra. PI [Internet]. 30Apr.2001 [cited 26Aug.2019];41(3-4):76-1. Available from:
Received 2017-02-01
Accepted 2017-02-01
Published 2001-04-30


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