Main Article Content
A study was conducted to analyze the multifactorial genetic inheritance pattern in prurigo Hebra (PH). Fifty
probands (PH patients) consisting of 11 males and 39 females, with age ranged from 5-30 years were included in this study.
A three-generation family tree was obtained from each subject, from which a total of 79 families were eligible for analysis. For
each family the possible mode of inheritance, namely autosomal dominant (AD) or autosomal recessive (AR), was predicted.
The families were then grouped according to the mode of inheritance. Analysis was conducted using Chi-square test,
comparing the observed occurrence of PH and the expected value for each mode. To rule out mutation, the second method
was applied, which only families with more than one affected child were analyzed, was used. The genetic inheritance
pattern was not consistently compatible either with AR or AD. This finding, and other supporting facts, such as female
preponderace, the role of HLA and the lower morbidity rate compared to the expected rate in AR or AD mode, indicated that
the genetic inheritance of PH follows a multi-factorial pattern.
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
2. McKenna RW, McKenna MW. Diseases of the skin. 6th edition. London: Billaire Tindall and Cox; 1952. p. 331-52.
3. Ormsby DS, Montgomery H. Disease of the skin. 6th edition. Philadelphia: Lea & Febriger, 1954. p. 197-203.
4. Rook A, Wilkinson DS, Ebling FJG. Eczema, lichen simplex and prurigo. In: Rook A, editor. Rook's Textbook of dermatology. London: Blackwell Scientific Publication; 1972. p. 84-9, 291-8.
5. Arnold HL, Odomm RB, James WD. Andrews' diseases of the skin: clinical dermatology, 8th edition. Philadelphia: WB Saunders Company; 1990. p. 157-8.
6. Kocsard E. The problem of prurigo. Austr J Dermatol 1962;6:156-66.
7. Rook A. Skin diseases caused by arthropodesand other venomous or noxious animals. In: Rook A, editor. Textbook of dermatology, 4th edition. Oxford : Blackwell Scientific Publicatons; 1986: p. 1031-8.
8. Pearson K. Extensions and application of genetics. In: Weaver RF, Hedrick PW, Editors. Genetics. Dubuque: Wm C, Brown Publisher;1989. p. 32-62.
9. Strickberger MW. Genetics. 2nd edition. New York: Macmillan Publishing Co. Inc; 1976. p. 125-39, 735-55.
10. Gehlehrter TD, Collins FS. Principle of medical genetics. Baltimore 1990. Williams and Wilkins. p. 1-68.
11. Thomson MW, Mc Innes RR, Williard HF. Genetics in medicine. 5th edition. Philadelphia: WB Saunders Company 1991. p. 349-63.
12. Der Kaloustian VM, Kurban AK. Genetic diseases of skin. Berlin: Springer Verlag; 1979. p. 1-16.
13. Butterworth T, Ladda RL. Clinical genodermatology. New York: Praeger Publisher; 1981. p. 1-35.
14. Standsfield WD. Genetics: Theory and problems. 3rd ed. New York: Churchill Livingstone; 1997. p.1-61, 249-68.16. Moeslichan SMz. Penelitian sistem HLA dalam upaya memperoleh sumber antibodinya. Disertasi. Jakarta: Universitas Indonesia 199. p. 9-59, 61-95,135.
17. Hall JR, Arnett FC. The HLA system and cutaneous diseases. In: Jordon RE, editor. Immunologic diseases of the skin. Connecticut: Appleton & Lange; 1991. p. 101-12.
18. Festenstein H, De'mant P. Hla and H2: Basic immunogenetics, biology and classic relevance. London: Edward Arnold Ltd; 1978. p. 16-84; 161-74.
19. Batchelor JR, McMechael AJ. Process in understanding HLA and disease association. In: Crumpton, Editor. HLA in medicine. Brit Med Bull vol 43, London. Churchill Livingstone for the British Council; 1987.p.157-893.
20. Cornain S. The significance HLA antigens in Dermatology. Med J Indones, 1995; 4:44-7.
21. Boediardja SA, Boedimulya U, Djuanda A, Muslichan SMz, Cornain S. The role of HLA in Prurigo Hebra. Med J Indones, 2001;9:1-11.
15. Occampo FA, Collade CM. Acute infantile prurigo: clionico-pathological correlation in 100 cases. Austr J Derm 1975; 16:169-73.