Oral contraceptive use and conotruncal congenital heart disease

  • Mars Nashrah Abdullah Department of Child Health, University of North Sumatera Medical School/H. Adam Malik Hospital
  • Muhammad Ali Department of Child Health, University of North Sumatera Medical School/H. Adam Malik Hospital
  • Melda Deliana Department of Child Health, University of North Sumatera Medical School/H. Adam Malik Hospital
  • Tina Christina L. Tobing Department of Child Health, University of North Sumatera Medical School/H. Adam Malik Hospital
DOI: https://doi.org/10.14238/pi54.6.2014.309-13
Keywords: oral contraceptive exposure, conotruncal congenital heart disease

Abstract

Background Congenital heart disease (CHD) represents some of the more prevalent malformations among live births and remains the leading cause of death from congenital malformations. Conotruncal anomalies comprise a diverse group of CHD involving the outflow tracts of the heart and the great vessels. Oral contraceptive exposure before pregnancy may be one of the risk factors for conotruncal CHD.

Objective To evaluate the effect of oral contraceptive use before pregnancy on the risk of conotruncal CHD in children.

Methods A case-control study was conducted from July 2010 until July 2011 in Haji Adam Malik Hospital, Medan. Subjects with CHD were divided into two groups: conotruncal CHD as the case group and non-conotruncal CHD as the control group. Both groups had mothers with and without histories of oral contraceptive use before pregnancy. Parents were interviewed using questionnaires. Statistical analyses were performed using Chi-square test, student’s T-test, and Mann Whitney test. Results A total of 80 subjects were eligible, with 40 subjects in each group. The percentages of subjects whose mothers used oral contraceptives were 62% of the conotruncal CHD group and 60% of the non-conotruncal CHD group (OR 0.82; 95%CI 0.33 to 1.98). The mean duration of maternal oral contraceptive use before pregnancy was 19.1 months for the case group and 18.8
months for the control group (P=0.87).

Conclusion In children with CHD, maternal oral contraceptive use before pregnancy does not appear to increase the risk of conotruncal CHD.

References

1. Saifuddin AB. Dinamika kependudukan dan keluarga berencana. In: Wiknjosasro H, Saifuddin AB, Rachimhadhi T, editors. Ilmu kebidanan. 3rd ed. Jakarta: Yayasan Bina Pustaka Sarwono Prawirohardjo; 2006. p. 889-903.
2. Baziad A. Kontrasepsi hormonal. Jakarta: Yayasan Bina Pustaka Sarwono Prawirohardjo; 2002. p. 1-50.
3. The American College of Obstetricians and Gynacologists Committee. Contraceptives and congenital anomalies. Int J Gynecol Obstet. 1993;42:316-7.
4. Malik S, Cleves MA, Zhao W, Correa A, Hobbs CA. Association between congenital heart disease and small for gestational age. Pediatrics. 2007;119:e976-82.
5. Bernstein D. The cardiovascular system. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, editors. Nelson textbook of pediatrics. 18th ed. Philadelphia: Saunders Elsevier; 2007. p. 1851-4.
6. The Executive of the Society of Obstetricians and Gynecologists of Canada. Principles of human teratology: drug, chemical, and infectious exposure. J Obstet Gynecol Com. 2007;199:911-6.
7. Pradat P, Francannet C, Harris JA, Robert E. The epidemiology of cardiovascular defects, part I: a study based on data from three large registries of congenital malformations. Pediatr Cardiol. 2003;24:195-221.
8. Harris JA, Francannet C, Pradat P, Robert E. The epidemiology of cardiovascular defects, part 2: a study based on data from three large registries of congenital malformations. Pediatr Cardiol. 2003;24:222-35.
9. Goldmuntz E, Clark BJ, Mitchell LE, Jawad AF, Cuneo BF, Reed L, et al. Frequency of 22q11 deletions in patients with conotruncal defects. J Am Coll Cardiol. 1998;32:492-8.
10. Reefhuis J, Honein MA. Maternal age and non-chromosomal birth defects, Atlanta 1968-2000: teenager or thirtysomething, who is at risk? Birth Defects Res A Clin Mol Teratol. 2004;70:572-9.
11. Carmichael SL, Ma C, Shaw GM. Socioeconomic measures, orofacial clefts, and conotruncal heart defects in California. Birth Defects Res A Clin Mol Teratol. 2009;85:850-7.
12. Botto LD, Correa A, Erickson JD. Racial and temporal variations in the prevalence of heart defects. Pediatrics. 2001;107:32.
13. Adams MM, Mulinare J, Dooley K. Risk factors for conotruncal cardiac defects in Atlanta. J Am Coll Cardiol. 1989;14:432-42.
14. De Santis MD, Cavaliere AF, Straface G, Carducci B, Caruso A. Failure of emergency contraceptive levonorgestrel and the risk of adverse effects in pregnancy and on fetal development: an observational cohort study. Fertil Steril. 2005;84:296-9.
15. Pizzo TSD, Sanseverino MTV, Mengue SS. Exposure to misoprostol and hormones during pregnancy and risk of congenital anomalies. Cad Saude Publica. 2008;24:1447- 53.
16. Posaci C, Smitz J, Camus M, Osmanagaoglu K, Devroey P. Progesterone for the luteal support of assisted reproductive technologies: clinical options. Hum Reprod. 2000;15:129- 48.
17. Fisher B, Rose NC, Carey JC. Principles and practice of teratology for the obstetrician. Clin Obstet Gynecol. 2008;51:106-18.
Published
2014-12-30
How to Cite
1.
Abdullah M, Ali M, Deliana M, Tobing T. Oral contraceptive use and conotruncal congenital heart disease. PI [Internet]. 30Dec.2014 [cited 24Nov.2024];54(6):309-3. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1231
Issue
Vol 54 No 6 (2014): November 2014
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Articles

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Received 2017-02-01
Accepted 2017-02-01
Published 2014-12-30