Comparison of the efficacy of artemether-lumefantrine vs. artesunate plus sulfadoxine-pyrimethamine in children with uncomplicated falciparum malaria
Abstract
Background World Health Organization (WHO) has recommended
that countries with drug resistant malaria problem use
combination therapies, especially artemisinin-based combination
therapy (ACT). However, there is limited information on the
efficacy of ACT in North Sulawesi.
Objective To compare the efficacy of artemether-lumefanttine and
artesunate plus sulfadoxine-pyrimethamine (SP).
Methods This was a randomized experimental study, conducted in
Prof. Dr. R. D. Kandou General Hospital, Manado from January
until July 2009. There were 42 patients aged less than 13 years
treated with artemether-lumefanttine and artesunate plus SP. Body
temperature, parasite and gametocyte count were recorded every
day until day 7 and follow-up reviews were done on day 14 and
28.
Results Fever clearance time showed a significant difference
between artemether-lumefanttine group (median 27 hours) and
artesunate plus SP group (median 18 hours), P<0.05). There was
no significant difference in parasite clearance time (P>0.05) and
game tocyte clearance time (P > 0. 05) . The 28 day cure rate were
100% in the two groups. No side effect was found.
Conclusion Both artemether-lumefanttine and artesunate plus SP
combination are effective and safe for the treatment of falciparum
malaria in children.
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Accepted 2017-01-29
Published 2010-04-30
