Evaluation of Bio M pylori serologic test and C-13 urea breath test for H. pylori infection in children with recurrent abdominal pain: a pilot study

Mira Dewita; Badriul Hegar Syarif; Sudigdo Sastroasmoro

doi:10.14238/pi50.2.2010.101-104

Mira Dewita Department of Child Health, Medical School, University of Indonesia, Cipto Mangunkusumo Hospital
Badriul Hegar Syarif Department of Child Health, Medical School, University of Indonesia, Cipto Mangunkusumo Hospital
Sudigdo Sastroasmoro Department of Child Health, Medical School, University of Indonesia, Cipto Mangunkusumo Hospital

DOI: https://doi.org/10.14238/pi50.2.2010.101-104

Keywords: H. pylori infection, recurrent abdominal pain, Bio M Pylori serologic test, urea breath test

Abstract

Background Diagnosing Helicobacter pylori infection in children
is still a problem. Urea breath test is the gold standard for noninvasive
diagnostic test, but it is expensive and not available in
most hospitals. The Bio M Pylori serologic test has good diagnostic
value in adults, less expensive and more practical, but had never
been evaluated in children.
Objective To determine the prevalence of H. pylori infection and
the diagnostic accuracy of Bio M Pylori serologic test in children
with recurrent abdominal pain.
Methods This study was conducted in May - June 2009. Children
aged 12-15 years with recurrent abdominal pain were examined
with urea breath test and the Bio M Pylori serologic test.
Sensitivity, specificity, area under the curve (AUC), predictive
values, and likelihood ratios were calculated for the Bio M Pylori
serologic test.
Results Most subjects aged 13 years (83%). Girls outnumbered
boys, and most were undernourished. The prevalence ofH. pylori
infection detected by urea breath test and Bio M Pylori serologic
test was 8% and 52%, respectively. The Bio M Pylori serologic
test had sensitivity and specificity of 100% and 53%, respectively.
Area under the curve (AUC) was 0.764. Positive and negative
predictive values were 16 and 100%, whereas positive and
negative likelihood ratios are 2.12 and 0. The overall accuracy
of this test is 5 7%
Conclusions The Bio M Pylori serologic test has high sensitivity
value (100%). This diagnostic kit can be considered as a good
pre-endoscopic screening tool in children with recurrent
abdominal pain caused by H. pylori infection.

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