Change of ionized calcium level in the first 48 hours of age of preterm newborns administered with two different dosages of intravenous calcium gluconate

  • Anton Wibowo Department of Child Health, Medical School, Padjadjaran University, Hasan Sadikin General Hospital
  • Dedi Rachmadi Sambas Department of Child Health, Medical School, Padjadjaran University, Hasan Sadikin General Hospital
  • Abdurachman Sukadi Department of Child Health, Medical School, Padjadjaran University, Hasan Sadikin General Hospital
DOI: https://doi.org/10.14238/pi50.2.2010.96-100
Keywords: Preterm newborn, early onset hypocalcemia, 10% calcium gluconate

Abstract

Background Physiologically, serum calcium level declines till nadir
in a few hours after birth and continues for 24-48 hours. No study
performed in order to know the alteration ofionized calcium level
of newborn in the first 48 hours of age. The sick newborn must
have parenteral calcium to avoid hypocalcemia but there is still
no agreement about the dose.
Objective To determine the change of ionized calcium level in
the first 48 hours of age of preterm newborns administered with
peripheral drip intravenous 10% calcium gluconate of2.6 mIJkg/
day and 5 mUkg/day.
Methods An open labeled randomized controlled clinical trial
was performed between April and June 2009. After birth blood
specimen of preterms was obtained for leukocyte, platelet,
magnesium, phosphorous, and ionized calcium measurements.
Subjects received either 2.6 mL/kg/day or 5 mL/kg/day of
peripheral drip intravenous 10% calcium gluconate immediately
after birth for 48 hours. Blood specimens was obtained again on
48 hours of age for ionized calcium. This study were analyzed
using repeated measures analysis of varians.
Results Forty preterm newborns (20 subjects each group) were
analyzed. There was no statistical difference between both
doses (Factor-A) on 48 hours ionized calcium level (P=0.33)
and ionized calcium level alteration based on time (Factor-B)
(P=0.20). Interaction between both factors was significantly
different (P=0.035).
Conclusion Ionized calcium level in 48 hours of age of preterm
newborn administered with both doses of 10% calcium gluconate is
not different but dose of2.6 mL/kg/day yields physiologic alteration
of ionized calcium level compared with 5 mL/kg/day.

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Published
2010-04-30
How to Cite
1.
Wibowo A, Sambas D, Sukadi A. Change of ionized calcium level in the first 48 hours of age of preterm newborns administered with two different dosages of intravenous calcium gluconate. PI [Internet]. 30Apr.2010 [cited 22Nov.2024];50(2):96-00. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1213
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Vol 50 No 2 (2010): March 2010
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Received 2017-01-29
Accepted 2017-01-29
Published 2010-04-30