Prevalence and clinical characteristics of rotavirus diarrhea in Mataram, Lombok, Indonesia

Main Article Content

Wayan Sulaksmana Sandhi Parwata
Wayan Sukardi
Abdul Wahab
Yati Soenarto

Abstract

diarrhea and dehydration among children aged <5 years in developed and developing countries, including Indonesia. There have been few studies on the prevalence of rotavirus diarrhea in Mataram.
Objective To determine the prevalence and characteristics of rotavirus diarrhea in children under five years of age with acute diarrhea in Mataram.
Methods A cross sectional study using the WHO Generic Protocol for Rotavirus Surveillance was conducted in the Nusa Tenggara Barat (NTB) General Hospital, Mataram, as part of a multicenter study by the Indonesian Rotavirus Surveillance Network (IRSN) for children under five years of age. Subjects were diagnosed with rotavirus diarrhea based on stool sample examinations, using RT-PCR for genotyping. They were admitted to the Pediatrics Ward of the NTB Provincial General Hospital from January to December 2010.
Results Of 329 children admitted with acute diarrhea, 210 (63.8%) had rotavirus positive stool specimens. For the year 2010, the highest incidence of rotavirus infection was in the month of January (86.4%). Rotavirus infections were found in children less than 2 years of age (65.4%), with the highest prevalence in the age group of 6 to 23 months (68.5%). In addition to clinical symptoms of watery diarrhea, there was a significantly greater percentage of vomiting in rotaviral vs. non-rotaviral diarrhea (67.7% vs. 32.3%, respectively; P<0.05). The majority of G and P genotypes found were G1 (86%), G2 (12%), P[8] (66%), P[4] (12.8%), and P[6] (8%).
Conclusion Rotavirus infections are the most common cause of acute diarrhea in children aged <2 years in Mataram, Indonesia.

Article Details

How to Cite
1.
Parwata WSS, Sukardi W, Wahab A, Soenarto Y. Prevalence and clinical characteristics of rotavirus diarrhea in Mataram, Lombok, Indonesia. PI [Internet]. 19Jul.2016 [cited 28Nov.2020];56(2):118-3. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/120
Section
Pediatric Gastrohepatology
Received 2016-07-19
Accepted 2016-07-19
Published 2016-07-19

References

1. Subijanto M, Fardah A, Ranuh G. Vaksinasi rotavirus pada anak. In: Purnomo B, Karpan F, Sugeng S, Narendra M,M Noor, Oetomo T, editors. Kumpulan Makalah Continuing Education Ilmu Kesehatan Anak FF Unair. Surabaya: FK Unair; 2007. p.149.
2. Centers for Disease Control and Prevention. Rotavirus surveillance----worldwide, 2009. MMWR Morb Mortal Wkly Rep. 2011;60;514-6.
3. Firmansyah A, Soenarto Y. Rotavirus. In: Ranuh IGN, Suyitno H, Hadinegoro S, Kartasasmita B, Ismoedijanto, Soedjatmiko, penyunting. Buku Pedoman Immunisasi Di Indonesia. 4th ed. Satgas Immnunisasi IDAI. Jakarta: Badan penerbit IDAI; 2011. p. 318-23.
4. Proceeding Rakernas dan Simposium Ilmiah Perhimpunan Gastro-Hepatologi dan Nutrisi Anak Indonesia (PGHNAI); 2012 May 3-5; Bandung, West Java, Indonesia.
5. Soenarto Y, Aman AT, Bakri A, Waluya H, Firmansyah A, Kadim M, et al. Burden of severe rotavirus diarrhea in Indonesia. J Infect Dis. 2009;200suppl 1:S188-94.
6. Bresee J, Fang ZY, Wang B, Nelson EA, Tam J, Soenarto Y, et al. First report from the Asian Rotavirus Surveillance Network. Emerg Infect Dis. 2004;10:988-95.
7. Hasibuan B, Nasution F, Guntur. Infeksi rotavirus pada anak usia di bawah dua tahun. Sari Pediatri. 2011;13:165-8.
8. Wilopo SA, Kilgore P, Kosen S, et al. Assessing the costs of introducing the rotavirus vaccine into Indonesia’s national immunization programme. Vaccine Supplement: Rotavirus in Indonesia (in press).
9. Munos MK, Walker CL, Black RE. The effect of rotavirus vaccine on diarrhoea mortality. Int J Epidemol. 2010;39:156-62.
10. WHO. Generic protocols for (i) hospital-base surveillance to estimate the burden of rotavirus gastroenteritis in children (ii) a community base survey on utilization of health care services for gastroenteritis in children. Field test version. Geneva: World Health Organization; 2002. [cited 2008 January 6]. Available from: http://www.who.int/vacccines-ducuments/DocsPDF02www698.pdf.
11. da Rosa e Silva ML, Naveca FG, Pires de Carvalho I. Epidemiological aspects of rotavirus infections in Minas Gerais, Brazil. Braz J Infect Dis. 2001;5:215-22.
12. Clemens J, Rao M, Ahmed F, Ward R, Huda S, Chakraborty J, et al. Breast-feeding and the risk of life-threatening rotavirus diarrhea: prevention or postponement? Pediatrics. 1993;92:680-5.
13. Tjitrasari T, Firmansyah A, Chair I. Clinical manifestations of rotavirus diarrhea in the outpatient clinic of Cipto Mangunkusumo Hospital, Jakarta. Paediatr Indones. 2005;45:69-75.
14. Hassine-Zaafrane M, Sdiri-Loulizi K, Ben Salem I, Kaplon J, Ayouni S, Ambert-Balay K, et al. The molecular epidemiology of circulating rotaviruses: three-year surveillance in the region of Monastir, Tunisia. BMC Infect Dis. 2011;11:266.