Thiamphenicol in the treatment of cholera in children

  • Haroen Noerasid Department of Child Health, Airlangga University Medical School/Dr. Soetomo Hospital, Surabaya, East Java
  • Eko Sujanto Department of Child Health, Airlangga University Medical School/Dr. Soetomo Hospital, Surabaya, East Java
  • Ismoedijanto Ismoedijanto Department of Child Health, Airlangga University Medical School/Dr. Soetomo Hospital, Surabaya, East Java
  • Djoko Soejono Department of Child Health, Airlangga University Medical School/Dr. Soetomo Hospital, Surabaya, East Java
  • I. G. G. Djelantik Department of Child Health, Airlangga University Medical School/Dr. Soetomo Hospital, Surabaya, East Java
  • Surata Surata Department of Child Health, Airlangga University Medical School/Dr. Soetomo Hospital, Surabaya, East Java
Keywords: thiamphenicol, cholera, tetracycline

Abstract

A study has been performed to measure the efficacy of thiamphenicol by comparing it with tetracycline as a standard drug. Eighty bacteriologically confirmed cholera patients were included in this study.

Among them, 41 patients were treated with thiamphenicol while the other39 with tetracycline.

Stool volume, duration of diarrhea and duration of hospitalization were higher in the thiamphenicol group. And the volume of intravenous and oral fluid therapy were less in the tetracycline group.

Positive bacteriologic examinations of the second samples (taken on the second day of hospitalisation) of the thiamphenicol grollp were 41.46% as compared with 17.94% of the tetracycline group. But almost all o{ the third samples of both groups were negative.

Clinical success rate of thiamphellicol was 95.12% and tetracycline was 100%. Thiamphenicol appeared to be effective against cholera in children.

References

1. BONANG, G. and SANTOSO, U.S. The in vitro sensitivity of vibrio strains to thiamphenicol. Mod. Med. Asia. 13: 10-11 (1977).
2. GUTMAN, R.A. and DRUTZ. D.I Double blind fluid therapy evaluation in Pediatric Cholera. Pediatr. 44: 922 – 931 (1969).
3. KAGAN. U.M. Antimicrobial Therapy. 2nd Ed. p. 95 • 104 (Saunders Philadelphia 1974).
4. KARCHMER, A.W., CURLIN. G.T., HUG, M.I. and HIRSCHORN. N.; Furazalidone in Pediatric cholera. Bull. Wld. Hlth. Org. 43: 373-378 (1970).
5. KOBARI, A.W., TAKAKURA. I., NAKATOMI, M., SEGAWE, S. and HYANGGO, C. : Antibiotic resistant strains of El Tor Vibrio in the Philippines and the use of Furalazine for chemotherapy. Bull. Wld. Hlth. Org. 43: 365-371 (1970).
6. LINDENBAUM, I., GORDON, R.S. Jr., HIRSCHORN, N., AKBAR. R., GREENBURGH, W.B. and ISLAM, M.R.: Cholera in children. London 1 : 1066 (1966).
7. LINDENBAUM. I., GREENBURGH, W.B. and ISLAM, M.R. Antibiotic therapy of cholera in children. Bull. Wld. HIth. Org. 37: 529-538 (1967).
Published
1981-10-30
How to Cite
1.
Noerasid H, Sujanto E, Ismoedijanto I, Soejono D, Djelantik IGG, Surata S. Thiamphenicol in the treatment of cholera in children. PI [Internet]. 30Oct.1981 [cited 20May2024];21(9-10):197-04. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1197
Received 2017-01-26
Accepted 2017-01-26
Published 1981-10-30