Neonatal tetanus treated with diazepam as single antispasmodic agent

  • Taslim Soetomenggolo Department of Child, University of Indonesia Medical School/Dr. Cipto Mangunkusumo Hospital, Jakarta
  • Ratna Heni Purboyo Department of Child, University of Indonesia Medical School/Dr. Cipto Mangunkusumo Hospital, Jakarta
  • S. K. Hendarto Department of Child, University of Indonesia Medical School/Dr. Cipto Mangunkusumo Hospital, Jakarta
  • Sofyan Ismael Department of Child, University of Indonesia Medical School/Dr. Cipto Mangunkusumo Hospital, Jakarta
DOI: https://doi.org/10.14238/pi21.5-6.1981.101-6
Keywords: tetanus, diazeepam, antispasmodic agent

Abstract

The use of diazepam as single antispasm in treating neonatal tetanus is better than the conventional therapy with the combination of Phenobarbital chlorpromazine and diazepam. The dose of diazepam 10 mg/kg body weight/day can be increased for very severe cases. The overall mortality of this study is 50%. Incubation period of less than 7 day and temperature on admission of more than 39°C are important factors to contribute to the high mortality. The critical period of neonatal tetanus is 15 days.

References

I. ELLIS, M.: Br. med. J. t; 1123 (1963) (cited by D. FEMI - PEARSE, 1966).
2. FEMl-PEARSE, D.: Experience with diazepam in tetanus. Br. med. /. 2 :862 - 865 (1966).
3. JENKINS, M.T. and LUHN, N.R.: Anesthesiology23 690 (1962).
4. KHOO, B.H.; LEE, E.L. nnd LAM,K.L. : Role of high dose valium (diazepam) in the management of neonatal tetanus. Abstracts of 31rd Asian Congr.Pediatr. in Bangkok, p. 31 (1979).
5. LIEM, W.T.; DARMAWAN, S; ISMAEL•S; SUDIGMA, IGN,; SURADI, S. and MUNTHE, B.G. : The effect of diazepam on tetanus. Paediatr. Indones. 10:248•258 (1970).
6. R ANDALL, L.O.; HEISE, G.A.; SCALLEK,W.; BAGDON, R.E.; BANZIGER,R.; BORIS, A.; MOE, R.A. and ABRAMS,W.B.: CMT. Res. 3: 405 (1961).405 (1961).
7. SMYTHE, P.M.; BOWIE, M.D. and VOS., T.J.V.: Treatment of tetanus neonatorum with muscle relaxants and intermittent positive-pressure ventilalion Br.med. J. 1 : 233 - 226 (1974).
8. SUTEJO; HENDARTO HENDARMIN; SUTARJONO and S.K. HENDARTO: Tracheotomy as an additional treatment of neonatal tetanus. Paediatr. Indones. 6 : 183 (1966).
9. SUTEJO and SOFYAN ISMAEL: Management of tetanus in South-East Asia. Med Prog. 2 : 17 - 18 (1975).
Published
1981-06-30
How to Cite
1.
Soetomenggolo T, Purboyo R, Hendarto S, Ismael S. Neonatal tetanus treated with diazepam as single antispasmodic agent. PI [Internet]. 30Jun.1981 [cited 20Apr.2024];21(5-6):101-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1166
Issue
Vol 21 No 5-6 (1981): May - June 1981
Section
Articles

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Received 2017-01-19
Accepted 2017-01-19
Published 1981-06-30