The role of glucomannan fiber in childhood functional constipation

Main Article Content

Indiana Aulia
Supriatmo Supriatmo
Emil Azlin
Atan Baas Sinuhaji

Abstract

its most common type is functional constipation. The dietary fiber may be useful in childhood functional constipation management, but unfortunately the role of fiber in functional constipation is still less developed.
Objective To determine the role of glucomannan in treatment of childhood functional constipation.
Methods A crossover randomized controlled trial (RCT) was done from May until July 2012 in a boarding school in Medan, North Sumatera. The subjects were children with functional constipation aged 7 to 12 years. Subjects were randomised into two group receiving glucomannan fiber as polysaccharide gel (group A) and maltodextrin as placebo (group B) with each dose of 100 mg/kg/day (maximum of 5 g/day) diluted in 50 ml water/500 mg for 4 weeks, then after a wash out period we did the crossover of the two groups. Frequency and consistency of stools were recorded into diary sheet for 4 and 8 weeks of treatment. Functional constipation has been diagnosed based on Rome III criteria. Data was analyzed using independent T-test and Chi-square test.
Results A total of 36 subjects were eligible with each group consisting of 18 subjects and mean of weight of 25 kg. We found significant difference in stool frequency, treated on glucomannan with P= 0.002 before and P = 0.0001 after the wash out period. For stool consistency, we found difference while treated on glucomannan 9/18 (P= 0.034) in 4 weeks before and 11/18 (P = 0.008) in 4 weeks after the wash out period.
Conclusion Glucomannan has significant effect to improve functional constipation especially in 4 weeks treatment.

Article Details

How to Cite
1.
Aulia I, Supriatmo S, Azlin E, Sinuhaji AB. The role of glucomannan fiber in childhood functional constipation. PI [Internet]. 19Jul.2016 [cited 16Oct.2019];56(2):95-00. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/116
Section
Pediatric Gastrohepatology
Received 2016-07-19
Accepted 2016-07-19
Published 2016-07-19

References

1. Jufri M, Soenarto YS, Oswari H, Arief S, Rosalina I, Mulyani SN. Gastroenterologi-hepatologi. 1st edition. Jakarta: IDAI; 2010. p.201-14.
2. Mohit K, Satya P, Anupam S. Constipation in children. JIMSA. 2012; 25:31-3.
3. Baucke VL. Prevalence rate for constipation and fecal and urinary incontinence. Archs Dis Child. 2007; 92:486-9.
4. Saps M. A prospective community-based study of gastroenterological symptoms in school age children. J Pediatr Gastroenterol Nutr. 2006; 43:477-82.
5. Anna Sant’ DA. Constipation in school-aged children at public schools in Rio de Janeiro, Brazil. J Pediatr Gastroenterol Nutr. 1999; 29:190-3.
6. Ozturk R, Rao SC. Defecation disorders: an important subgrup of functional constipation, its pathophysiology, evaluation and treatment with biofeedback. Turk J Gastroenterol 2007; 18:139-149.
7. Hong Li Z, Dong M, Wang Z. Functional constipation in children: investigation and management of anorectal motility. World J Pediatr. 2008; 8:47-8.
8. Farnam A, Rfeey M, Farhang S, Khodjastejafari S. Functional constipation in children: does maternal personality matter?. Ital J Pediatr. 2009; 35:1-4.
9. Andrea H, Anna C, Hania S. Functional constipation in children: a follow up of two randomized controlled trials. Pediatria Polska. 2013; 219-223.
10. Keithley J, Swanson B. Glucommanan and obesity: a critical review. Altern Ther Health Med. 2005; 11:30-34.
11. Freddy T. Childhood constipation: diagnosis, treatment, and the role of dietary fiber. 1st edition. Zeist: A-D Druk BV, 2011. p.40-8.
12. Sande A, Osorio T, Lopez R. Glucomannan. Eur J Pharm Biopharm. 2009; 72:453-62.
13. Baucke VL, Miele E, Staiano A. Fiber (glucomannan) is beneficial in the treatment of chilhood constipation. Pediatrics. 2004; 113:e259-e64.
14. Anna C, Andrea H, Piotr D, Hania S. Glucomannan is not effective for the treatment of functional constipation in children : a double-blind, placebo-controlled, randomized trial. Clinical Nutrition. 2011; 30:462-8.
15. Yang J, Wang HP, Zhou L, Xu CF. Effect of dietary fiber on constipation: a metaanalysis. World J Gastroenterol. 2012; 18:7378-83.
16. William C, Bollella M, Wynder E. A new recommendation for dietary fiber in childhood. Pediatrics. 1995; 96:985-88.
17. Staiano A, Simeone D, Del Giudice E, Miele E, Tozzi A, Toraldo C. Effect of the dietary fiber glucomannan on chronic constipation in neurologically impaired children. J Pediatr. 2000; 136:41-45.
18. Anne RL. Managing functional constipation in children. Pediatr Child Health. 2011; 16:661-5.