Effect of oral administration of probiotics on intestinal colonization with drug-resistant bacteria in preterm infants

Abdullah Kurt; Deniz Anuk Ince; AyÅŸe Ecevit; Ã–zlem Kurt Azap; Zafer Ecevit; Ersin Ã–ÄŸÃ¼ÅŸ; Ali UlaÅŸ TuÄŸcu; Aylin Tarcan

doi:10.14238/pi57.2.2017.91-8

Abdullah Kurt Department of Neonatology , Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey
Deniz Anuk Ince Department of Neonatology , Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey
AyÅŸe Ecevit Department of Neonatology , Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey
Ã–zlem Kurt Azap Department of Neonatology , Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey
Zafer Ecevit Department of Neonatology , Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey
Ersin Ã–ÄŸÃ¼ÅŸ Department of Neonatology , Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey
Ali UlaÅŸ TuÄŸcu Department of Neonatology , Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey
Aylin Tarcan Department of Neonatology , Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey

DOI: https://doi.org/10.14238/pi57.2.2017.91-8

Keywords: preterm, probiotic, bacterial colonization

Abstract

Background Oral administration of probiotics in newborn preterm infants has been shown to be helpful, especially Ä±n reducÄ±ng the incidence of necrotizing enterocolitis and overall mortality rates.

Objective To evaluate the effect of probÄ±otÄ±c supplementation on Ä±ntestÄ±nal colonization by antibiotic-resistant microorganisms in preterm infants receiving antibiotics in a neonatal intensive care unit (NICU).

Methods The prospective, randomized trial was performed Ä±n preterm infants who were hospitalized in the NICU at Baskent University Ankara Hospital between January 2011 and February 2012. A total of 51 infants were enrolled and randomly assigned to one of two groups: Group 1 (n=27) received probiotic therapy and Group 2 (n=24) did not receive probiotics. The probiotic used was Lactobacillus reuteri (BiogaiaÂ® AB, Sweden).Â Subjects underwent weekly nasal swab and stool cultures for a maxÄ±mum of 6 weeks, and at the tÄ±me of dÄ±scharge Ä±f thÄ±s was prÄ±or to 6 weeks. All posÄ±tÄ±ve cultures were further tested for culture-specÄ±fÄ±c Ä±dentÄ±fÄ±catÄ±on and antÄ±bÄ±otÄ±c suceptibility.

Results Â A total of 607 cultures were evaluated. PosÄ±tÄ±ve cultures were found Ä±n 37.9% from Group 1 and 35.2% from Group 2. IntestÄ±nal colonÄ±zatÄ±on by antÄ±bÄ±otÄ±c-resÄ±stant bacterÄ±a dÄ±d not sÄ±gnÄ±fÄ±cantly dÄ±ffer between groups (P>0.05).Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â

Conclusions Oral supplementation with probiotics do not prevent the intestÄ±nal colonization of antibiotic-resistant microorganisms in preterm NICU patÄ±ents who receÄ±ved antÄ±bÄ±otÄ±c treatment.

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