Immunological aspects of persistent hepatitis B in children

Main Article Content

Harsoyo Notoatmojo

Abstract

We studied the immunological status of 203 children having persistence Hepatitis B (positive HBsAg) ranging in age from 6 to 14 years in Semarang Municipality. The results of humoral immunity examination (IgM Anti-HBc) showed that all were negative, indicating that they are not in acute phase of hepatitis B infection. Cellular immunity examination, i.e., CMI skin test has shown positive result in 64.9% on persistent and 65.2% in non persistent hepatitis B (p>0.05). T cell examination showed statistically significant difference (p<0.01) between persistenct and non persistent hepatitis B patients, there was is also significant difference (p<0.01) on CD4 cell examination. These findings indicated that there was difference in immunoregulation function and response repression of antivirus between both groups of patients. On the other hand CD4/ CD8 ratio and T cell function showed no significant difference between the two gorups of patients; similarly the specific function of cytotoxic T cell was not significantly difference.

Article Details

How to Cite
1.
Notoatmojo H. Immunological aspects of persistent hepatitis B in children. PI [Internet]. 30Aug.2006 [cited 19Nov.2019];41(7-8):208-3. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1078
Section
Articles
Received 2016-11-23
Accepted 2016-11-23
Published 2006-08-30

References

1. Alberti A, Cavalletto D, Pontiso P, Chemello L, Tagariello G, Belussi F. Antibody Response to Pre-S2 and Hepatitis B Induced Liver Damage. Lancet 1988; 1:1421-
23.
2. Alberti SA, Diana S, Eddleston ALWF, Scullard GH. Detection of a new antibody system reacting with Dane particles in hepatitis B virus infection. BMJ 1978; 2:1056-58.
3. Dientag JL. Immunologic mechanism in chronic viral hepatitis. In: Vyas GN, Dientag JL, Hoofnagle J, editors. Viral Hepatitis and Liver Disease. New York: Grune and Stratton Inc., 1984;135-164.
4. Eddleston ALWF, Mondelli M, Mieli-Vergan IG, Alpert A. et al. Lymphocytes cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection. Hepatology
1982;2:122S-127S.
5. Eddleston ALWF. Immunological aspects of hepatitis B infection. In: Zuckerman A, Allan R, editors. Viral hepatitis and liver diseases. New York: Liss Inc., 1988;603-605.
6. Kiyosawa K, Wada S, Imai Y, et al. Significance of IgM antibody to hepatitis B core antigen for the differential diagnosis of acute and chronic hepatitis B virus infection and for the evaluation of the inflammatory activity of type B chronic liver diseases. Gastroenterology Japonica 1986;21:6.
7. Brunetto MR, Cerenzia MT, Oliveri F, et al. Monitoring the natural caurse and response to therapy of chronic hepatitis B with an automated semi-quantitative assay for IgM anti-HBc. J. Hepatol 1993;19:431-436.
8. Barnaba W, Musca A, Cordova C, Levrero M, Ruocco G, Balsanof. Relationship betwee n T cell subsets and supressor cell activity in chronic hepatitis B virus infection.
Clin. Exp. Immunol.1983;53:281-288.
9. Neurath AR., Kent S.B.H., Strick N. The biological role of pre-S sequences in the hepatitis B virus envelope protein : Implication for vaccine design. Proceeding of Asian
symposium on strategies for large scale Hepatitis B immunization. Hong Kong June 12-13, 1986;97-112.
10. Stites DP and Terr AI. Basic and clinical immunology. Prentice-Hall Intern. Inc. USA. 1991.
11. Dienfeng Z, Bangyuan L, Zuchong L and Fengsheng C. Cell-mediated immune response in viral hepatitis B. Chinese Med. J 1980;2:90-97.
12. Dienstag JL. Immunologic mechanism in chronic viral hepatitis. In: Vyas GN, Dientag JL, Hoofnagle JH, editors. Viral hepatitis and liver disease. New York: Grune & Stratton Inc.,1984.
13. Eddleston ALEF. Overview of HBV pathogenesis. In: Hollinger FB, Lemon SM, Margolis H, editors. Viral hepatitis and liver disease. Baltimore: Williams & Wilkins, 1990.
14. Aoyama K, Kojima T, Inoue K, Sasaki H. Immunohistochemical investigation of hepatitis B virus associated antigens, HLA antigens and lymphocyte subsets in type B chronic hepatitis. Gastroenterologia Japonica 1990;25:41-53.
15. Mondelli M, Vergai GM, Alberti A, et al. Specificity of T lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection : evidence that T cells
are directed against HBV core antigen expressed on hepatocytes. J. Immun. 1982;129:6.