Congenital uronephropathy pattern in children

Main Article Content

Husein Alatas
Natalina Soesilawati
Bambang Madiyono

Abstract

To obtain the basic data of congenital uronephropathy pattern and the affecting factors in children, we conducted a cross-sectional study at the Department of Child Health Cipto Mangunkusumo (CM) Hospital Jakarta from 1995 to 1999 and 9 teaching hospitals throughout Indonesia. During the study period 134 patients were obtained, 116 patients from the CM Hospital and 18 patients from other teaching hospitals. Most patients (48.8%) were below 1 year of age; male were affected more than female (2.4:1). The disorder was classified into two groups, i.e., congenital nephropathy and uropathy. There were 10 children with nephropathy, i.e., 4 with unilateral renal hypoplasia, 3 with polycystic kidney, and 3 with renal agenesis. In the uropathy group, 43 were with hypospadia, 22 with primary reflux vesicoureter, 18 with neurogenic bladder, and 17 with ureteropelvic junction obstruction. The complications found were urinary tract infection (71.2%), chronic renal failure (15.7%), hypertension (3.7%), and acute renal failure (1.5%). Consanguinity, familial disorders, maternal diseases, x-ray exposure and abortion efforts were found in a small proportion of patients. History of drug or herbs use in the first trimester of pregnancy was found in a large proportion of patients, mostly took analgesics (especially acetaminophen). In conclusion, uropathy disorders were much more common than congenital nephropathy. The most common complication was urinary tract infection, followed by chronic renal failure, hypertension, and acute renal failure.

Article Details

How to Cite
1.
Alatas H, Soesilawati N, Madiyono B. Congenital uronephropathy pattern in children. PI [Internet]. 30Oct.2001 [cited 27Nov.2020];41(9-10):241-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1060
Section
Articles
Received 2016-11-21
Accepted 2016-11-21
Published 2001-10-30

References

1. Becker N, Avner ED. Congenital nephropathies and uropathies. Pediatr Clin North Am 1995; 42:1319-41.
2. Harper PS. Practical genetic counseling; 4th ed. Oxfort: Butterworth Heinemann, 1994. p. 6-7.
3. Kadri N, Siregar SP, Surachman H, Suradi R. Cacat bawaan di bangsal bayi baru lahir Rumah Sakit Dr. Cipto Mangunkusumo 1975-1979. Maj Obstet Ginek Indones 1982; 8;94-100.
4. Lubis B, Tjipta GD, Panjaitan, Raid N, Siregar H. Congenital malformation among newborns at Dr. Pirngadi hospital Medan during 1981-1984. Paediatr Indones 1989; 29: 1-7.
5. Kaplan BS, Fay J, Shah V, Dillon MJ, Barratt TM. Autosomal recessive polycystic kidney disease. Pediatr Nephrol 1989; 3:43-49.
6. Tambunan T, Madiyono B, Sihombing R. Vesico-ureteric reflux with and without reflux nephropathy in children with urinary tract infection. Paediatr Indones. (In print).
7. Scott JES. The management of ureteric reflux in children. Br J Urol 1977;49:109-118.
8. Tamminen-Mobius T, Brunier E, Ebel KD, Lebowitz R, Olbing H,Seppanen U, et al. Cessation of vesicoureteral reflux for 5 years in infants and children allocated to medical
treatment. The International Reflux Study in children; European branch. J Urol 1992;148(2): 1662-6.
9. Alatas H, Karyomenggolo WT. Kelainan kongenital ginjal dan saluran kemih. In: Pramuljo HS, Nurhamzah W, Zacharia J, editer. Pencitraan traktus urinarius pada anak.
Naskah Lengkap Pendidikan Berkelanjutan Ilmu Kesehatan Anak FKUI XXVI; 11-12 September 1992; Jakarta: Balai Penerbit FKUI, 1992.
10. Belman BA. Vesicoureteral reflux. Pediatr Clin North Am 1997; 44: 1171-89.
11. Alatas H. Gagal ginjal akut. In: Alatas H, Tambunan T, Trihono PP, editer. Nefrologi anak jilid II. Jakarta: Balai Penerbit FKUI, 1996; 446-64.
12. Renick J, Vernier RL. Renal cystic diseases and renal dysplasia. In: Holliday MA, Barratt TM, Vernier RL, penyunting. Pediatric nephrology; 2nd ed. Baltimore: Williams
& Wilkins, 1987. p. 371- 83.
13. Drummond KN. Developmental abnormalities of the kidney and urinary collecting system. In: Behrman RE, Vaughan VC, Nelson WE, editer. Textbook of pediatrics; 12th ed. Philadelphia: Saunders, 1983. p. 1373-6.
14. Karlowicz MG, Adelman RD. Acute renal failure in the neonate. Clin Perinatol 1992; 19: 139-55.
15. Anand SK. Acute renal failure in the neonate. Pediatr Clin North Am 1982; 29: 791-800.
16. Firdaoessaleh. Uropati obstruktif pada anak-anak. In: Wila Wirya IGN, Alatas H, Tambunan T, Trihono PP, editer. Penanggulangan masalah uronefrologi pada anak. Naskah lengkap Pendidikan Kedokteran Berkelanjutan Ilmu Kesehatan Anak FKUI XXIX; 24-25 September 1993; Jakarta: Balai Penerbit FKUI, 1993.
17. Tambunan T, Wila Wirya IGN, Madiyono. Hypertension and chronic atrophic Pyelonephritis result of nephrectomy (case report). Paediatr Indones 1973; 13: 303-9.
18. Buyse ML. Birth defects encyclopedia. Dover: Blackwell Scientific Publication, 1990. p. 226, 1008-9.
19. Sekarwana N. Gagal ginjal kronik. In: Alatas H, Tambunan T, Trihono PP, editer. Nefrologi anak jilid II. Jakarta: Balai Penerbit FKUI, 1996; 465-86.
20. Thulstrup AM, Strensen HT, Nielsen GL, Andersen L, Barrett D, Vilstrup H, et al. Fetal growth and adverse birth outcomes in women receiving prescriptions for acetaminophen during pregnancy. Am J Perinatol 1999; 16:7, 321-6 (abstract).
21. Markum AH, Monintja HE, Boedjang RF. Janin dan neonatus. In: Markum AH, Ismael S, Alatas H, Akib A, Firmansyah A, Sastroasmoro S, editer. Buku ajar ilmu kesehatan anak. Jakarta: Balai Penerbit FKUI, 1991. p.205-8.
22. Ferner RE. Teratogenic drugs an update. Adverse Drug Reaction Bulletin 1993; 161:607-9.
23. Lazjuk GI, Nikolaev DL, Novikova IV. Changes in registered ca in the Republic of Belarus after the Chernobyl accident. Stem Cell 1997; 15 Suppl 2, 255-60.
24. Miller RW. Effects of pranatal exposure to ionizing radiation. Health Phys 1990; 59:1,57-61.
25. Li DK, Checkoway H, Mueller BA. Electric blanket use during pregnancy in relation to the risk of congenital urinary tract anomalies among women with a history of subfertility. Epidemiology 1995;6:5, 485-9.
26. Kadri N, Siregar SP, Surachman H, Suradi R. Cacat bawaan di bangsal bayi baru lahir Rumah Sakit Dr. Cipto Mangunkusumo 1975-1979. Maj Obstet Ginek Indones 1982; 8;94-100.