Nephritogenicity of glomerular basement membrane: a molecular aspect

  • Syarifuddin Rauf Department of Child Health,Hasanuddin University Medical School/Dr. Wahidin Sudirohusodo Hospital, Makassar
Keywords: glomerulonephritis, glomerular basement membrane, nephritogenic antiaging

Abstract

Glomerular basement membrane (GBM) has multifunctions. One of its functions is having nephritogenicitywhich means the ability of an antigen originally from GBM in causing glomerulonephritis, either in experimental animal or in human being. Recent studies on GBM have revealed that its main component is type IV collagen, consists of 6 different isoforms, α1 (IV) to α 6 (IV) chains. Genetic studies show that all of the six α chains are encoded by genes located in 2, 13, and X chromosomes. Nephritogenic antigen in GBM has been identified as α3, α4, α5 chains. They are molecules of type IV collagen located in globular domain (NC1 domain) at the carboxyl terminus of the type IV collagen of GBM. They are thought to assemble into a α3- α4- α5 (IV) chain helical molecules in human GBM. Other α chains, namely α1 and α2 chain, are not nephritogenic or poorly nephritogenic, while the α6 chain is not located in GBM. The nephritogenicity of GBM has been elucidated as a cause in experimental anti-GMB nephritis, and in Goodpasture and Alport syndromes.

References

1. Sado Y, Kagawa M, Naito I, Ueki Y, Seki T, Momota R, et al. Organization and expression of basement membrane collagen IV genes and their roles in human disorders. J Biochem 1998;123:767–76.
2. Hudson BG, Wieslander J, Wisdom BJ, Noelken ME. Biology of disease: Goodpasture syndrome: molecular architecture and function of basement membrane antigen. Lab Invest 1989;61:256–69.
3. Brazel D, Obermaumer I, Dieringer H, Babel W, Glanville RW, Deutzmann R, et al. Complication of the amino acid sequence of ? 1 chain of human basement membrane collagen (type IV) reveals 21 nontripleinterruptions located with in the collagenous domain. Eur J Biochem 1987;168:529–36.
4. Brazel D, Pollner R, Obermaumer I, Kuhn K. Human basement membrane collagen (type IV). The amino acid sequence of the ? 2 (IV) and its comparison with the ? 1 (IV) chain reveals deletions in the ? 1 (IV) chain. Eur J Biochem 1988;172:35–42.
5. Mariyama M, Leinonen A, Mochizuki T, Tryggvason K, Reeders ST. Complete primary structure of the human ? 3 (IV) collagen chain : coexpression of the ? 3 (IV) and ? 4 (IV) collagen chains in human tissues. J Biol Chem 1994;269:23013–7.
6. Leinonen A, Mariyama M, Mochizuki T, Tryggvason K, Reeders ST. Complete primary structure of the human type IV collagen ? 4 (IV) chain. J Biol Chem 1994;269:26172–7.
7. Zhou J, Hertz JM, Leinonen A, Tryggvason K. Complete animo acid sequence of the human ? 5 (IV) collagen chain and identification of single-base mutation in exon 23 converting glycine 521 in the collagenous domain to cysteine in Alport syndrome patient. J Biol Chem 1992;269:12475–81.
8. Zhou J, Ding M, Zhao Z, Reeders ST. Complete primary structure of the sixth chain of human basement membrane collagen ? 6 (IV). J Biol Chem 1994;269:13193–9.
9. Wieslander J, Barr JF, Butkowsky RJ, Eair Sulingards SJ, Bygren P, Heinegard D, et al. Goodpasture antigen of the glomerular basement membrane: localization to non collagenous region of the type IV collagen. Proc. Natl Acad Sci USA 1984;81:3838–42.
10. Wieslander J, Langeveld J, Butkouski RJ, Jodlowski M, Noelken M, Hudson BG. Physical and immunohistochemical studies of the globular domain of the type IV collagen. J Biol Chem 1985;260:8564–70.
11. Butkowsky RJ, Wieslander J, Wisdom BJ, Barr JF, Noelken ME, Hudson BG. Properties of the globular domain and its relationship to the Goodpasture antigen. J Biol Chem 1985;260:3739–47
12. Butkowsky RJ, Langeveld JPM, Wieslander J, Hamilton J, Hudson BG. Localization of the Goodpasture epitope to a novel chain of basement membrane collagen. J Biol Chem 1987;262:7874–7.
13. Butkowsky RJ, Guo-Qiu Shen, Wieslander J, Michael AF, Fish AJ. Characterization of type IV collagen NC! monomers and Goodpasture antigen in human renal basement
membrane. J Lab Clin Med 1990;115:365–73.
14. Rauf S, Kagawa M, Kishiro Y, Inonue S, Naito I, Oohashi T, et al. Nephritogenicity and ? - chain composition of NC1 fraction of type IV collagen from bovine renal basement membrane. Virchows Arch 1996;428:281–8.
15. Sado Y, Kagawa M, Kishiro Y, Naito I, John K, Ninomiya Y. Purification and characterization of human nephrotigenic antigen that induces anti – GBM nephritis in rats. J Pathol 1997;182:225–32.
16. Ninomiya Y, Kagawa M, Iyama K, Naito I, Kishiro Y, Seyer JM, et al. Differential expression of two basement membrane collagen genes, Col 4 ? 6 and Col 4 ? 5, demonstrated by immunofluorescence staining using peptide-spesific monoclonal antibodies. J Cell Biol 1995;130:1219–29.
17. Steblay RW. Glomerulonephritis induced in sheep by injection of heterologous glomerular besement membrane and Freund’s complete adjuvant. J Exp med 1962;116:253–69.
18. Sado Y, Okogaki T, Takamiya H, Seno S. Experimental autoimmune glomerulonephritis with pulmonary haemorrhage in rats. The dose-effect relationship of the nephritogenic antigen from bovine glomerular basement membrane. J Clin Lab Immunol 1984;15:199–204.
19. Shibata S, Nagasaawa T, Mikayawa Y, Naruse T. Nephritogenic glycoprotein : proliferative glomerulonephritis induced in rats by single injection of the soluble glycoprotein isolated from homologous glomerular basement membrane. J Immunol 1971;106:1284–94.
20. Sado Y, Naito I. Experimental autoimmune glomerulonephritis in rats by soluble isologous or homologous antigen from glomerular and tubular basement membranes. Br J Path 1987;68:695–704.
21. Sado Y, Naito I, Okigaki T. Transfer of anti – glomerular basement membrane antibody –induced glomerulonephritis in inbred rats with isologous antibodies from the urine of nephritic rats. J Pathol 1989;158:325–32.
22. Sado Y, Kagawa M, Rauf S, Naito I, Moritoh C , Okigaki T. Isologous monoclonal antibodies can induce anti-GBM glomerulonephritis in rats. J Pathol 1992;168:221–7.
23. Sado Y, Naito I, Ninomiya Y. Expression of collagen IV genes and Goodpasture Antigens. In Y. Ninomiya, ed. Extracellular matrix–cellular interaction. Japan ScSOC Press Tokyo/S Kargo Basel; 1998. p. 235–60.
24. Gubler MC, Knebelmam B, Beziau A, Brayer M, Pirson Y, Haddoum F, et al. Autosomal recessive Alport syndrome: immunohistochemical study of type IV collagen
chain distribution. Kidney Int 1995;47:1142–7.
25. Naito I, Kawai S, Nomura S, Sado Y, Osawa G. The Japanese Alport Network. Relationship between Col 4A5 gene mutation and distribution of type IV collagen in male X-linked Alport syndrome. Kidney Int 1996;50:304–11.
26. Kagawa M, Kishiro Y, Naito I, Nemoto T, Nakamishi H, Ninomiya Y, et al. Epitope defined monoclonal antibodies against type IV colagen for diagnosis of Alport’s syndrome. Nephrol Dial Transport 1997;12:1238–41. 27. Rauf S. Penggunaan antibodi monoklonal untuk menunjang diagnosis sindrom Alport J Med Nus 1999;20:34–40.
28. Scolari F, Valzorio B, Fasciolo F, Carli O, Vizzarrdi V, Gaggia P, et al. Kidney transplantion in Alport’s syndrome. In: Sessa A, Conte F, Meroni M, Battini G, eds. Hereditary kidney diseases. Contrib. Nephrol Basel, Karger; 1997. p. 140–2.
Published
2001-12-31
How to Cite
1.
Rauf S. Nephritogenicity of glomerular basement membrane: a molecular aspect. PI [Internet]. 31Dec.2001 [cited 20May2024];41(11-12):273-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1041
Section
Review Article
Received 2016-11-17
Accepted 2016-11-17
Published 2001-12-31